Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Preoperative neutrophil-lymphocyte ratio and CEA is associated with poor prognosis in patients with synchronous colorectal cancer liver metastasis. 30941323 2019
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE ECOG (Eastern Cooperative Oncology Group) performance scores, CEA levels, CA19-9 levels, hemoglobin levels, lactate dehydrogenase levels, and liver metastasis ratios varied significantly between the low and high AGR groups (p < .05). 29785861 2019
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE This protein behaves similarly to CEA isolated from liver metastases of a colon tumor in its property of being resistant to cleavage by cyanogen bromide. 6200032 1983
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE CEA mRNA expression was also closely correlated with E-cadherin mRNA expression in the primary tumor (P<0.001) and in the adjacent hepatocytes of the liver metastasis (P=0.018). 14592671 2003
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Improved tumour marker sensitivity in detecting colorectal liver metastases by combined type IV collagen and CEA measurement. 26162539 2015
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE Moreover, high mtDNA content in tumor tissues was associated with larger tumor size, higher serum CEA level, advanced TNM stage, vascular emboli, and liver metastases. 27197581 2016
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Relevance of CEA and LDH in relation to KRAS status in patients with unresectable colorectal liver metastases. 28008623 2017
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE We analysed the gene expression profiles of EpCAM/CEA/AC133 and EpCAM/CEA/AC133 cells from primary CRC and liver metastasis tissues (n = 5). 21436631 2011
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE The result showed that the high expression of TLR9 was correlated with tumor poorly differentiation, invasion and liver metastasis, the abnomal increasing levels of CEA in blood. 30271180 2018
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE CEA mRNA was detected in all patients with synchronous liver metastases, even though there was no significant correlation between the presence of CEA mRNA in the drainage venous blood and the clinicopathological findings. 9697262 1998
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Thus, the systemic administration of AdCEAp/Rep was considered to be effective on multiple liver metastases of CEA-positive colon cancer in a xenograft model. 15564136 2004
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE A decreased overall survival was significantly associated with peritoneal involvement (HR 1.944; p = 0.003), ascites (HR 2.055; p = 0.034), synchronous presentation (HR 1.679; p = 0.034) and increased serum CEA levels (HR 1.380; p = 0.010), but not with age > 50 (HR 0.946; p = 0.743), menopausal status (HR 1.565; p = 0.204), gastric origin (HR 1.600; p = 0.201), size > 5 cm (HR 1.292; p = 0.119), size > 10 cm (HR 0.925; p = 0.714), bilateral ovarian involvement (HR 1.113; p = 0.347), non-peritoneal extaovarian metastases (HR 1.648; p = 0.237), liver metastases (HR 1.118, p = 0.555), predominant signet ring cell morphology (HR 1.322; p = 0.208) and levels of CA125 (HR 0.933; p = 0.828) and CA19.9 (HR 0.996; p = 0.992). 31542818 2019
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 GeneticVariation disease BEFREE The in vivo VDEPT experiment with RCM-1 and the adenovirus vector driven by the CEA promoter revealed attenuation of liver metastases in the treatment group. 12783317 2003
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE High platelet count (H-PC) was found in 32%, and it was associated with a higher rate of palliative surgery (p < 0.001), extra-hepatic metastases (p < 0.001), bilobar liver disease (p = 0.007), presence of more than three metastases (p = 0.005), biggest metastasis larger than 5 cm (p < 0.001), and CEA level higher than 200 ng/mL (p = 0.035). 30937817 2019
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE We conclude that MIC-1 can act as a candidate complementary biomarker for screening early-stage CRC by combination with CEA, and furthermore, for the first time, identify a promising prognostic indicator for monitoring recurrence with liver metastasis, to support strategies towards personalized therapy. 28206963 2017
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE CEA also enhances the survival of colorectal cancer cells in both local colonization and liver metastasis in animal study. 20889724 2010
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model. 10424738 1999
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE The aim of this study is to identify the network of genes that are associated with CEA-induced colorectal cancer liver metastasis. 27583792 2016
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE The liver tumor biopsies were obtained from 40 patients suffering from CLM treated with radical surgery. mRNA expression levels of CEA, MMPs and TIMPs and a housekeeping gene (GAPDH) were quantified using RT-PCR. 17992052 2007
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 AlteredExpression disease BEFREE Quantitative estimation of CEA and CK20 expression in tumour tissue of colorectal cancer and its liver metastases with reverse transcription and real-time PCR. 16739357 2006
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE Meanwhile, correlation of the CA19-9 and CEA content in serum with the progression of liver metastasis was analyzed. 25496480 2014
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE CEC detection was associated with female gender (p = 0.03) only, whereas CTC detection was associated with presence of the primary tumor (p = 0.007), metastasis size (p < 0.001), bilobar liver metastases (p = 0.02), CEA (p < 0.001) and CA 19-9 levels (p < 0.001). 28415583 2017
Entrez Id: 1087
Gene Symbol: CEACAM7
CEACAM7
0.100 Biomarker disease BEFREE The protein expression of Rab5A was examined in 390 CRC specimens and the results showed that high expression of Rab5A was significantly correlated with tumor size (P = 0.008), serum CEA (P = 0.002), liver metastasis (P = 0.014) and clinical stage (P = 0.010). 26261586 2015