Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 GeneticVariation disease BEFREE In patients with CRC, the -174 G>C polymorphism status of the IL-6 gene promoter affects the IL-6 serum level, particularly in the presence of hepatic metastasis. 12796383 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE The S1PR1-STAT3-IL-6-MDSCs axis operates in both tumor cells and MDSCs involved in the promotion of growth and liver metastasis in CRC. 31534132 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE However, higher IL-6 did not predict shorter survival.High serum IL-6 can be an independent risk factor for progression to extensive hepatic metastasis in PDAC patients. 28151872 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE A linear regression model predicted cfDNA levels from sum of longest tumor diameters by RECIST, the presence of liver metastases and systemic inflammatory response as measured by interleukin 6 (F(6, 357) = 62.7, P < 0.001). 31046124 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE In the liver metastasis xenograft model, LAP2β increased metastatic efficacy of gastric cancer cells and mortality in tested mice. cDNA microarrays showed the possibility that myristoylated alanine-rich C kinase substrate (MARCKS) and interleukin6 (IL6) may mediate LAP2β-regulated motility of cancer cells. 22745766 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE IL-6 increased mildly (up to 220 pg/ml) following vector administration to skin and lung airways of normal individuals and of individuals with CF, and to muscle and liver metastasis of individuals with PVD and colon cancer, respectively. 12349828 2002
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 Biomarker disease BEFREE Genetic ablation or blockade of components of IL-6-STAT3-SAA signalling prevents the establishment of a pro-metastatic niche and inhibits liver metastasis. 30842658 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 AlteredExpression disease BEFREE Patients with primary and secondary liver cancer showed significantly elevated levels of IL-6 and IL-8 but not CCL22 compared to healthy controls. 29899223 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.090 AlteredExpression disease BEFREE In conclusion, colorectal liver metastasis may be supported by CAFs and resident fibroblastic cells competent to generate a prometastatic microenvironment through inflammatory activation of IL-6 and MCP-1. 20617559 2010