Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 Biomarker disease BEFREE The expression of six genes was significantly different in primary tumors compared with their matched liver metastases [CXCR4 (p < 0.001), THBS1 (p = 0.007), MMP 9 (p = 0.048), GST Pi (p = 0.050), TYMP (p = 0.042) and DPYD (p < 0.001)]. 25301403 2015
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 GeneticVariation disease BEFREE Liver metastases (n = 93) along with primary tumors (n = 48) were analyzed for K-Ras mutations (codons 12 and 13), p53 mutations (exons 4-9), p53 polymorphism (codon 72), thymidylate synthase (TS) polymorphism (28-bp repeats including G>C mutation), methylenetetrahydrofolate reductase polymorphism (677C>T, 1298A>C), thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase activity, folylpolyglutamate synthase activity, and p53 protein expression. 18676755 2008
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE The mRNA expression ratios of DPD and TP showed a significant correlation both in primary sites and in liver metastases. 18630501 2008
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE No difference in DPD expression in liver metastasis samples was observed between exposed and unexposed patients. 17330233 2007
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 Biomarker disease BEFREE DPD and TP may affect the acquisition of resistance to 5-FU during liver metastasis of colorectal cancer. 16525674 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE Our aim was to determine how TS, DPD, TP and OPRT gene expression levels in primary colorectal cancer (CRC) were related to those in liver metastases. 16572420 2006
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE In both primary tumor and liver metastasis, the TS mRNA levels correlated significantly with the OPRT mRNA level (primary rS=0.83, P=0.00000081; liver metastasis rS=0.49, P=0.017), while the DPD mRNA level correlated significantly with the TP mRNA level rS=0.81, P=0.0000024; rS=0.63, P=0.0014; respectively). 15060742 2004
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. 12095978 2002
Entrez Id: 1806
Gene Symbol: DPYD
DPYD
0.090 AlteredExpression disease BEFREE Using a reverse transcription competitive PCR assay, we quantified DPD mRNA levels in 10 matched colorectal tumors and adjacent normal mucosae and 7 colorectal liver metastases and adjacent normal livers. 10499634 1999