Evaluation of [<sup>18</sup>F]FDG/[<sup>18</sup>F]FLT/[<sup>18</sup>F]FMISO-based micro-positron emission tomography in detection of liver metastasis in human colorectal cancer.
While VEGFR1 expression in pTU patients did not predict prognosis; high percentage of VEGFR1<sup>+</sup> cells in liver metastasis was associated with worse patient outcome.
Response Monitoring with [<sup>18</sup>F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.
Membrane VEGFR1 and VEGFR3 expressions were associated with the presence of lung metastasis; interestingly, VEGFR3 was associated with less liver metastasis.
Collectively, our results indicate that liver metastases are more reliant on VEGFR-1 than lung metastases to mediate angiogenesis due to differential activity of VEGFRs on liver EC versus lung EC.
The anti-Flt-1 ribozyme was then tested in a xenograft model of human metastatic colorectal cancer in which significant inhibition of liver metastasis was observed.