Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE Immunohistochemical detection of HIF1α protein in liver metastases confirmed its decreased nuclear expression after in vivo ZnSO<sub>4</sub> treatment. 30613921 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE The tumorigenicity of SYT7-knockout cells was moderately reduced in a mouse model of subcutaneous metastasis in which the levels of BCL2 and HIF1A were decreased and was more strikingly attenuated in a model of hepatic metastasis. 29858600 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 Biomarker disease BEFREE According to the immunohistochemistry results, ARK5 and HIF1-α staining was significantly associated with Tumor-Node-Metastasis stage, tumor grade, lymph node metastasis and liver metastasis. 29467884 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE A significant correlation was also observed between the expressions of HIF-1α and VEGF in liver metastases and primary tumors (p = 0.015, 0.024, respectively). 23748663 2013
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 Biomarker disease BEFREE Gene expression and localization of CD31, HIF-1α, members of the vascular endothelial growth factor (VEGF) and Angiopoietin (Ang) system were studied using qRT-PCR and immunohistochemistry in colorectal liver metastases and nontumorous-adjacent liver parenchyma. 22156924 2012
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE Liver metastases associated induction of proinvasive receptor tyrosine kinase Met phosphorylation as well as gelatinolytic activity were Hif-1alpha-dependent. 20566631 2010
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE In vivo optical imaging showed that HIF-1 activity proceeded along with local invasion, the peritoneal dissemination, and the liver metastasis. 19417024 2009
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 Biomarker disease BEFREE We analyzed the expressions of hexokinase II (HK II), a key enzyme in glycolysis, and VEGF in hepatocellular carcinoma (HCC) and metastatic liver cancer in relation to tumor vascularity, and the participation of hypoxia-inducible factor-1 (HIF-1) was studied. 14672622 2004
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.090 AlteredExpression disease BEFREE HIF-1alpha expression was correlated with tumor invasion, tumor stage, lymphatic invasion, venous invasion and liver metastasis. 12673675 2003