Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 Biomarker disease BEFREE We have tried to answer which molecular changes of the <i>IGF2</i> gene and its regulatory mechanisms have the most significance in initiation, progression (including liver metastasis), prognosis, and potential anti-IGF2 therapy in CRC patients. 31623387 2019
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 Biomarker disease BEFREE Hypermethylation of both the IGF2 DMR and the LINE1 was associated with more aggressive features of GC such as advanced stage (IGF2 DMR, P = 0.0002; LINE1, P < 0.0001), lymphatic invasion positive (IGF2 DMR, P = 0.004; LINE1, P = 0.002), venous invasion positive (IGF2 DMR, LINE1, both P = 0.03), lymph node metastasis positive (IGF2 DMR, P = 0.01; LINE1, P = 0.001), peritoneal dissemination positive (IGF2 DMR, P = 0.04; LINE1, P = 0.002), liver metastasis positive (IGF2 DMR, P = 0.008; LINE1, P = 0.001), and other distant metastasis positive (IGF2 DMR, P = 0.04). 28871451 2018
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 Biomarker disease BEFREE Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain. 20479215 2010
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 Biomarker disease BEFREE Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer. 18636198 2008
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 AlteredExpression disease BEFREE DT-A was preferentially expressed in liver metastases after being transfected with H19 or IGF2-P3 promoter-driven DT-A expression plasmids, causing a very significant inhibition of tumor growth as a result of its cytotoxic effect. 15521051 2005
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 AlteredExpression disease BEFREE IGF 2 expression levels were also measured by RT-PCR quantitative analysis in 18 liver metastases and 10 normal tissues from patients without cancer. 15192314 2004
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.070 AlteredExpression disease BEFREE To assess the relationship between insulin-like growth factor II (IGF2) and H19 gene expression at the cellular level, we have examined the distribution of IGF2 and H19 mRNA by means of an situ hybridization in hepatic malignancies consisting of hepatocellular carcinoma (HCC), cholangiocellular carcinoma (CCC), and metastatic liver cancer (MLC). 9609998 1998