Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | In both cohorts, exosomal miR-141-3p and miR-375 were higher in patients with synchronous liver metastasis than in those without (P = .010 and P = .017 respectively in the investigative cohort, and P < .001 for both in the validation cohort). | 31146167 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | In BALB/c mice injected with FaDu HNSCC cells, miR-141 mitigated hepatic metastasis and inhibited expression of EGFR, CDK4, bcl-2 and MMP2. | 30737360 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | NRP-1 depletion suppressed tumor growth and liver metastasis and miR-141 mimics inhibited the growth of established tumors in mice. | 31572065 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The probability of liver metastases in colorectal cancer patients was positively correlated with serum miR-141, miR-200b, and miR-200c expressions, which could be treated as new biomarker for early diagnosis of liver metastases in colorectal cancer. | 28617555 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Compared with the patients with colorectal cancer without liver metastasis, patients with liver metastasis had significantly higher serum levels of miR‑200 and miR‑141 (P<0.05). | 28944840 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Notably, overexpression of miR-141 also suppressed the liver metastasis of SW480 cells in nude mice. | 28739727 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Liver metastasis tissues showed higher expression of miR-200c (primary CRC = 1.31 vs. liver metastasis = 1.59; p = 0.0014) and miR-141 (primary CRC = 0.14 vs. liver metastasis = 0.17; p = 0.0234) than did primary CRCs, which was significantly associated with hypomethylation of the promoter region of these miRNAs (primary CRC = 61.2% vs. liver metastasis = 46.7%; p < 0.0001). | 22735571 | 2013 |