Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Moreover, SERPINA3 siRNA could not only reduce live metastasis of mice, but also down-regulate the expression of Mmp-2 and Mmp-9 in liver metastasis tissues. 29855767 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Moreover, these cells exhibited high metastasis in mice, and p-p65, MMP-2, and MMP-9 expression levels were elevated in the primary tumor and liver metastases. 26596835 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Overexpression of miR-29c suppresses pancreatic cancer liver metastasis in a nude mouse orthotopic implantation model. miR-29c expression was associated with metastasis and pancreatic cancer patient survival. miR-29c plays an important role in mediating pancreatic cancer metastasis to the liver by targeting MMP2. 25863127 2015
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Our experimental results suggest that HCS has some anti-metastasis potential to suppress the growth of liver metastasis by decreasing the expression of MMP-2 and MMP-9 as well as VEGF. 25496480 2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Regression analysis indicated that QYHJ possessed an evident inhibition against the progression of liver metastasis by downregulating the expression of VEGF and Cyr61 rather than MMP-2. 21382954 2012
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE MMP1 and MMP2 were identified as consistently underexpressed in liver metastasis compared with primary CRC. 21531813 2011
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE We investigated the differential expression of MMP-2, 7, 9, 11, and 13 and their endogenous inhibitors (TIMP-1, 2, and 3) by quantitative real-time RT-PCR in 25 primary tumors, their corresponding lymph node metastases and/or liver metastases and matched normal mucosa. 18708724 2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 Biomarker disease BEFREE These findings explain the efficacy of gelatinase-specific synthetic inhibitors on invasion and growth of tumor cells and attribute distinct functions of MMP-2 and MMP-9 to aspects of liver metastasis. 18337444 2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE In hepatocellular carcinoma and liver metastases, in situ hybridization showed that MMP2 and TIMP2 mRNA were expressed by anti-alpha-smooth muscle actin-positive cells at the invasive front. 9075667 1997
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE The levels of TIMP-1, MMP-2 and MMP-9 mRNA were significantly higher in primary colorectal cancers than in their adjacent normal tissues, and those of the mRNAs for all four genes were significantly higher in liver metastases than in normal colorectal tissues. 8895669 1996