In addition, Pearson correlation analysis revealed a significant correlation between <sup>18</sup>F-FMISO SUVmax ratio of CRLM mice and number of liver metastases larger than 0.5 cm, as well as between <sup>18</sup>F-FMISO SUVmax ratio and HIF-1α or GLUT-1 expression in tumor-bearing tissues.
GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p<0.001), T stage (n=6, OR=1.73, 95% CI=1.17-2.58, p=0.007), higher Dukes stage (n=5, OR=2.92, 95% CI=2.16-3.95, p<0.001), female sex (n=4, OR=2.92, 95% CI=2.16-3.95, p<0.001), and presence of liver metastasis (n=3, OR=1.82, 95% CI=1.06-3.12, p=0.03).
The mean value of GLUT1 was higher in primary tumors (50.390 ± 68.648) than in the corresponding normal mucosa (20.437 ± 28.703, p<0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 ± 68.648 vs 52.277 ± 52.482, p=0.190).