×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
Biomarker
disease
BEFREE
Additional studies are needed to confirm the usefulness of BACE1 , alone or in combination with other markers, in discriminating patients and predicting LOAD onset and progression.
31745860
2020
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
GeneticVariation
disease
BEFREE
Abbreviations: Alzheimer's disease (AD); Late-onset Alzheimer's disease (LOAD ); Early-onset Alzheimer's disease (EOAD); Shugoshin-1 (Sgo1); Chromosome Instability (CIN); apolipoprotein (Apoe); Central nervous system (CNS); Amyloid precursor protein (APP); N-methyl-d-aspartate (NMDA); Hazard ratio (HR); Cyclin-dependent kinase (CDK); Chronic Atrial Intestinal Dysrhythmia (CAID); beta-secretase 1 (BACE ); phosphor-Histone H3 (p-H3); Research and development (R&D); Non-steroidal anti-inflammatory drugs (NSAIDs); Brain blood barrier (BBB).
30231670
2018
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
AlteredExpression
disease
BEFREE
Our findings provide a mechanistic role of BIN1 in the pathogenesis of AD as a novel genetic regulator of BACE1 levels and Aβ production.
27179792
2016
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
Biomarker
disease
BEFREE
We collected blood DNA from 120 late-onset Alzheimer's disease (AD) patients and 115 healthy matched controls and analysed the methylation levels of genes involved in amyloid-beta peptide production (PSEN1 and BACE1 ), in DNA methylation (DNMT1, DNMT3A and DNMT3B), and in one-carbon metabolism (MTHFR), searching for correlation with age and gender, with biomarkers of one-carbon metabolism (plasma homocysteine, and serum folate and vitamin B12 levels), and with disease status (being healthy or having AD ).
26079324
2015
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
GeneticVariation
disease
BEFREE
LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD ).
23750206
2013
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
Biomarker
disease
BEFREE
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease .
17098871
2006
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
Biomarker
disease
CTD_human
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
16407166
2006
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
GeneticVariation
disease
BEFREE
These results suggest that BACE1 gene polymorphism C786G might act as an APOE epsilon4 allele-dependent risk factor for developing LOAD in Chinese.
15784960
2005
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
GeneticVariation
disease
BEFREE
Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.
12707937
2003
×
Entrez Id:
23621
Gene Symbol:
BACE1
BACE1
0.390
Biomarker
disease
BEFREE
The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease .
11234778
2001