Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.170 | Biomarker | disease | HPO | |||||||
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0.170 | AlteredExpression | disease | BEFREE | A drastic diminution of β-synuclein expression was observed in cortical areas of all samples that presented neuropathological features corresponding to pure diffuse Lewy body pathology and the clinical phenotype of dementia with Lewy bodies, but not in those with neuropathological features corresponding to diffuse Lewy body pathology and concomitant Alzheimer's disease pathology or the clinical phenotype of Parkinson's disease with dementia. | 20959308 | 2010 | ||||
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0.170 | Biomarker | disease | BEFREE | Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients. | 29278715 | 2018 | ||||
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0.170 | Biomarker | disease | BEFREE | First, all BS isoforms are drastically diminished in the cortex of patients with pure LBP that had presented clinically as DLB but not PD with dementia. | 22205345 | 2012 | ||||
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0.170 | Biomarker | disease | BEFREE | In this study, we examined the expression patterns of neuronal maturation markers in the brain of a mouse model of dementia with Lewy body-linked mutant β-synuclein (βS), especially in the hippocampus, to explore whether such brain abnormalities occur in neurodegenerative disorders as well. | 29976232 | 2018 | ||||
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0.170 | AlteredExpression | disease | BEFREE | Our findings provide new insights into the pathogenesis of dementia in PD, indicating that differential BS and AS expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases. | 21683963 | 2011 | ||||
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0.170 | Biomarker | disease | BEFREE | The synuclein family has long been associated with Parkinson's disease and dementia. | 28963338 | 2017 | ||||
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0.170 | GeneticVariation | disease | BEFREE | The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson's disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB) as the second most frequent cause of dementia after Alzheimer's disease and multiple system atrophy. | 29370097 | 2018 |