Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 Biomarker disease BEFREE In this study, we examined the expression patterns of neuronal maturation markers in the brain of a mouse model of dementia with Lewy body-linked mutant β-synuclein (βS), especially in the hippocampus, to explore whether such brain abnormalities occur in neurodegenerative disorders as well. 29976232 2018
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 GeneticVariation disease BEFREE The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson's disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB) as the second most frequent cause of dementia after Alzheimer's disease and multiple system atrophy. 29370097 2018
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 Biomarker disease BEFREE Accumulation of beta-synuclein in cortical neurons is associated with autophagy attenuation in the brains of dementia with Lewy body patients. 29278715 2018
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 Biomarker disease BEFREE The synuclein family has long been associated with Parkinson's disease and dementia. 28963338 2017
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 Biomarker disease BEFREE First, all BS isoforms are drastically diminished in the cortex of patients with pure LBP that had presented clinically as DLB but not PD with dementia. 22205345 2012
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 AlteredExpression disease BEFREE Our findings provide new insights into the pathogenesis of dementia in PD, indicating that differential BS and AS expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases. 21683963 2011
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 AlteredExpression disease BEFREE A drastic diminution of β-synuclein expression was observed in cortical areas of all samples that presented neuropathological features corresponding to pure diffuse Lewy body pathology and the clinical phenotype of dementia with Lewy bodies, but not in those with neuropathological features corresponding to diffuse Lewy body pathology and concomitant Alzheimer's disease pathology or the clinical phenotype of Parkinson's disease with dementia. 20959308 2010
Entrez Id: 6620
Gene Symbol: SNCB
SNCB
0.170 Biomarker disease HPO