We used data from the National Longitudinal Study of Adolescent Health (Add Health) to examine the effects of two dopamine receptor genes (the dopamine D2 receptor gene (DRD2) and the dopamine D4 receptor gene (DRD4)), drug-using peers, neighbourhood problems, low self-control, public assistance, age, race, and gender on delinquency abstention.
Contrary to our expectations, results showed that carriers of the dopamine receptor D4 gene 4-repeat homozygous variant instead of those carrying the 7-repeat allele were more susceptible to the effects of both peer victimization and social well-being on delinquency later in adolescence.
In addition, a significant interaction emerged, indicating that adolescents carrying two copies of the 5-HTTLPR short allele and the DRD4 7r variant scored highest on aggressive and/or delinquent behavior compared to other genotypes.
In this study, we investigated whether high parental psychological control and low support would be differentially related to the development of delinquency in adolescents based on their genetic background (i.e., DRD4 and DRD2 genotypes).
Further, the two genotype combinations that differed the most in expression levels (BDNF Val66Met Val, 5-HTTLPR LL, MAOA-uVNTR LL [girls] and L [boys] vs BDNF Val66Met Val/Met, 5-HTTLPR S/LS, MAOA-uVNTR S/SS/LS) in interaction with family conflict and sexual abuse were associated with the highest delinquency scores.
The low expressing allele of the MAOA-uVNTR genotype (MAOAL) interacted with abuse to predict self-reports of less serious criminal and delinquent behavior and had a direct association with serious criminal activity.
The results revealed that all three perspectives have considerable empirical support, where neuropsychological deficits interact with the MAOA genotype to predict adolescent delinquency and levels of self-control for White males.
Keller, 2014), latent growth modeling revealed a significant interaction of DRD2 × Parental Support, indicating that adolescents with the DRD2 A2A2 genotype were more vulnerable for low parental support, developing more delinquent behavior as a consequence.
Functional variants of the MAOA-uVNTR, 5-HTTLPR, and BDNF Val66Met, either alone or in interaction with each other, may be best conceptualized as modifying sensitivity to environmental factors that confer either risk or protection for teenage delinquency.
In addition, a significant interaction emerged, indicating that adolescents carrying two copies of the 5-HTTLPR short allele and the DRD4 7r variant scored highest on aggressive and/or delinquent behavior compared to other genotypes.
Several studies have suggested an association between antisocial, aggressive, and delinquent behavior and the short variant of the serotonin transporter gene polymorphism (5-HTTLPR).
The results of the analyses revealed a gene X environment interaction between the A-1 allele of DRD2 and religiosity in the prediction of adolescent delinquency.
This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency.
Aggression and attention problems were also significantly affected by the ALDH2 polymorphism, whereas no significant association was observed between the ALDH2 polymorphism and delinquency, anxiety, or depression.
Platelet MAO-B activity has been associated with psychopathy- and aggression-related personality traits, while variants of the MAOA and MAOB genes have been associated with diverse clinical phenotypes, including aggressiveness, antisocial problems and violent delinquency.
Functional variants of the MAOA-uVNTR, 5-HTTLPR, and BDNFVal66Met, either alone or in interaction with each other, may be best conceptualized as modifying sensitivity to environmental factors that confer either risk or protection for teenage delinquency.
Compared with FTO-CINI youth who had not smoked recently, recent smokers endorsed more emotional and behavioral symptoms, such as school problems (<i>p</i> < .001), internalizing problems (<i>p</i> = .012), inattention/hyperactivity (<i>p</i> = .020), affect dysregulation (<i>p</i> = .044), PTSD symptoms (<i>p</i> = .006), and delinquent behavior (<i>p</i> < .001).
Contrary to our expectations, results showed that carriers of the dopamine receptor D4 gene 4-repeat homozygous variant instead of those carrying the 7-repeat allele were more susceptible to the effects of both peer victimization and social well-being on delinquency later in adolescence.
Three dopamine genes (DAT1, DRD2, and DRD4) have been associated with interpersonal delinquency, aggression, and violence when individuals experience adverse environmental exposures.
Both environmental factors and genetic variation, particularly in genes responsible for the dopaminergic system such as DRD4, DRD2, and DAT1 (SLC6A3), affect adolescent delinquency.
We used data from the National Longitudinal Study of Adolescent Health (Add Health) to examine the effects of two dopamine receptor genes (the dopamine D2 receptor gene (DRD2) and the dopamine D4 receptor gene (DRD4)), drug-using peers, neighbourhood problems, low self-control, public assistance, age, race, and gender on delinquency abstention.
This investigation examined the genetic (A), and shared (C) and nonshared (E) environmental variance contributions to the relationship of self-reported delinquency (as measured by the "Delinquent Behavior Inventory" [DBI; Gibson, 1967]) to the Socialization (So) scale of the California Psychological Inventory using univariate and bivariate structural equation models.