Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress. 12829623 2003
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Resistin SNPs and haplotypes were not associated with body mass index (BMI), fasting glucose, insulin resistance, metabolic syndrome, adipokines or CAC scores. 18710472 2009
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Many resistin gene polymorphisms were described and their implication in obesity and metabolic syndrome (MetS) was controversial. 23020084 2012
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Our data suggest that the presence of the -420C/G SNP of the resistin gene is associated with increased obesity and metabolic syndrome, although it is not different in subjects at high cardiovascular risk such as patients with myocardial infarction or patients with renal dysfunction compared with controls. 17598818 2007
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE A concentration of leptin > 52.18 pg/ml (AUC = 0.81, <i>p</i> < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, <i>p</i> = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS. 28721146 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Increased resistin in TJA+MetS, but not in TJA-MetS, compared to normal, suggests that while elevated resistin levels may be associated with the osteoarthritic process, levels are further attenuated by MetS, which is highly prevalent in this population. 26871396 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Obesity was associated with higher adiponectin-resistin index value in sera (P < 0.0001) and decreased in subcutaneous adipose tissue (P < 0.001), but only adiponectin-resistin index measured in sera was significantly higher in obese with the metabolic syndrome (P = 0.04). 29213336 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. 29847844 2018
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE The present results point that high leptin, resistin and ghrelin levels may be involved in the early pathophysiological process which can lead to later obesity and MeS in patients with bipolar disorder. 29132244 2018
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE None of these SNPs at the adiponectin and resistin loci were associated with T2DM and MS susceptibility in Malaysian men. 21323646 2011
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE In the 264 unrelated probands, resistin levels were significantly (P < 0.01) correlated with adiposity, blood pressure, C-reactive protein, and the metabolic syndrome score. 16670163 2006
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Based on our study findings, we concluded that mutations in resistin genes are not associated with the presence of MetS in a Han Chinese population from Jilin province in China. 29386698 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE Although the associations between adiponectin, leptin, resistin and metabolic abnormalities in our paediatric population were similar to those in adults, correlations of FGF21 levels with obesity, IR and MetS were the inverse of those found in adults. 28139438 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Glucose metabolism was assessed by static (glucose, insulin, adiponectin, leptin and resistin plasma concentrations) and dynamic (disposition index, insulin sensitivity index, HOMA-IR and acute insulin response to glucose) indices, performed at baseline and after 12 weeks of 4 dietary interventions (high saturated fatty acid (SFA), high monounsaturated fatty acid (MUFA), low-fat and low-fat-high-n3 polyunsaturated fatty acid (PUFA)) in 486 subjects with MetS. 22269963 2013
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Therefore, we conducted a genome-wide association study (GWAS) to identify quantitative trait loci associated with resistin levels and investigated whether these variants were prospectively associated with the development of metabolic syndrome (MetS) and T2DM in an independent community-based cohort, the CardioVascular Disease risk FACtors Two-township Study (CVDFACTS). 24123702 2014
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE IL-6, IL-1beta and resistin did not demonstrate any correlations with the metabolic syndrome in either group. 16320084 2005
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements. 29075331 2017
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE The prevalence of MetS was high in ASS patients that also had serum resistin and low leptin levels. 29716676 2018
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Present study shows that 420C/G polymorphism of resistin gene directly correlated to its high circulating level and metabolic risk factors, specifically markers of obesity and atherosclerosis, so it may have an important role in the development of metabolic syndrome and cardio metabolic diseases. 25088792 2014
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE According to RETN +62G>A polymorphism, carriers with the A allele (GA/AA) had significantly increased resistin levels than subjects with the GG genotype, consequently, the RETN +62G>A polymorphism was found to be related to MS, biochemical parameters and anthropometric variables. 31820685 2019
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Therefore, the frequent SNP +299G>A in the resistin gene is unlikely to have major effects on susceptibility to insulin resistance syndrome associated with type 2 diabetes in Japanese subjects. 12965109 2003
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 GeneticVariation disease BEFREE Interleukin-6 G-174C gene polymorphism and serum resistin levels in North Indian women: potential risk of metabolic syndrome. 21177727 2011
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE Leptin, resistin, and adipsin levels were significantly increased in the obese and MS groups. 31404407 2019
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 AlteredExpression disease BEFREE Plasma resistin levels were not found to be associated with MS and type 2 diabetes. 19805902 2009
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.400 Biomarker disease BEFREE Human and animal studies on relationships between resistin and MetS (initiation and progression of components) were included in our search. 29991083 2018