Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 GeneticVariation disease BEFREE rs6259 and rs3760213 SNPs are associated with the risk of MetS and lower serum SHBG level in Chinese Han males. 24671943 2014
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease CTD_human Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. 17992261 2007
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE This relationship was also observed in MetS components (BMI and SBP). 30157802 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE To examine whether expression of human <i>SHBG</i> in mice may ameliorate the development of diabetes and metabolic syndrome in response to a high-fat diet (HFD). 29141991 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013. 29245159 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE AChE activity was associated with BP status and SBP, whereas BChE activity was associated with features of the metabolic syndrome (especially body weight and BMI). 21493754 2011
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Besides, sex, age, WC, SBP, DBP, ALT, FG, UAC, TG, HDL-C and LDL-C are risk factors for MetS after multivariate adjustment. 28740055 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Together, this body of evidence indicates that sex steroids and SHBG should be routinely incorporated into clinical characterization of T2D patients, particularly in screening prediabetic patients, such as those with metabolic syndrome, using plasma levels of SHBG. 27990781 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to identify and summarize the relationships between muscular fitness (MF) and individual components of metabolic syndrome (high waist circumference [WC], high blood pressure [BP], high systolic BP [SBP], high diastolic BP [DBP], high triglycerides [TG], fasting blood glucose [FG], and low HDL cholesterol levels [HDL-C]) in children and adolescents. 30273286 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE Correlations between the levels of biochemical parameters and the levels of hormones in serum and the prostate tissue of BPH patients with and without MetS demonstrate that serum SHBG levels correlated weakly with waist size and triglyceride levels. 30122909 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE Testosterone (free and total) and SHBG were significantly lower in MetS subjects and modestly reduced in type 2 DM with and without MetS. 30057912 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels. 28577342 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE MetS patients had lower levels of total testosterone (P = 0.001), sex hormone-binding globulin, inhibin B, and anti-Mόllerian hormone (all P ≤ 0.03), and they were hypogonadal at a higher prevalence (P = 0.01) than patients without MetS. 27004539 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE This SHBG decrease is more pronounced in girls with premature pubarche who are at risk to develop functional ovarian hyperandrogenism as well as insulin resistance syndrome. 11117669 2000
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 GeneticVariation disease BEFREE A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. 25647406 2015
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome. 30478933 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE SHBG mRNA and protein levels were lower in patients with metabolic syndrome than in those without metabolic syndrome; however, these differences were significant only for mRNA level. 30496542 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk. 26441241 2015
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Low endogenous testosterone and sex hormone-binding globulin (SHBG) concentrations have been reported to be associated with metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). 31068503 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 GeneticVariation disease BEFREE Eight of them were normotensive and eleven hypertensive according to MetS threshold (≥130 mmHg for SBP and/or ≥85 mmHg for DBP). 28493030 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 AlteredExpression disease BEFREE Lower levels of sex hormone-binding globulin increase risks of MetS and T2DM in both sexes. 29241756 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 GeneticVariation disease BEFREE We analyzed the allele frequencies of SHBG gene polymorphisms in relation to the risk components of MetS. 23788303 2013
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 GeneticVariation disease BEFREE Among the subjects who developed the MetS those with the Pro12Pro genotype (n = 3) had significantly lower levels of SHBG compared to subjects with X12Ala (n = 8) (13.23 vs 28 nmol/L, p = 0.025). 17322577 2006
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease CTD_human We hypothesized that high levels of testosterone, dehydroepiandrosterone sulfate (DHEA-S), and cortisol and low levels of sex hormone-binding globulin (SHBG) and IGF-I would be associated with MetS in a representative cohort of older Italian women independently of confounders (including inflammatory markers). 16968811 2007
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.400 Biomarker disease BEFREE Simple logistic analysis showed that sex (OR 3.50, 95% CI 1.21-10.12, p = 0.021), age (OR 1.14, 95% CI 1.07-1.21, p<0.001), BMI (OR 1.11, 95% CI 1.01-1.22, p = 0.028), waist circumference (OR 1.06, 95% CI 1.02-1.10, p = 0.002), SBP (OR 1.03, 95% CI 1.01-1.04, p = 0.003), DBP (OR 1.03, 95% CI 1.00-1.06, p = 0.030), HDL-C (OR 0.97, 95% CI 0.94-1.00, p = 0.026), uric acid (OR 1.84, 95% CI 1.49-2.27, p<0.001), metabolic syndrome (OR 2.68, 95% CI 1.29-5.67, p = 0.009), and decreased BMD (OR 3.998, 95% CI 1.38-11.57, p = 0.011) were significantly associated with CKD. 29320555 2018