Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. 12161548 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE We conclude that PPARgamma gene polymorphism may be a reliable indicator of whether exercise will have a beneficial effect as part of the treatment of insulin resistance syndrome. 12601634 2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome. 12630956 2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation. 12788836 2003
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE My aim in addressing the issue of the potential impact of PPAR-gamma receptor agonists on cardiovascular disease (CVD) morbidity and mortality in the diabetic, is first, to seek to enhance both an awareness of, and greater familiarity among our own physicians, with this class of drug, and secondly, to effect a timely review of the recent literature as it relates to the tremendous possibilities for the potential clinical gains that might accrue from their use, in so far as this may serve to ameliorate the ravages of the CVD disease that all too tragically attends the type 2 diabetic, and more specifically those with the insulin resistance syndrome. 15524180 2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE However, this evolutionary adaptation to store energy in fat, which can be released under the form of fatty acids, potent PPARgamma agonists, has become a disadvantage in today's affluent society as it results in numerous metabolic imbalances, collectively known as the metabolic syndrome. 15667578 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE The PPARKI mouse provides a novel model for studying the relationship between impaired PPARgamma function and the metabolic syndrome. 15716267 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease RGD Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats. 16183630 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. 16186413 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents. 16216916 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Effects of two common polymorphisms of peroxisome proliferator-activated receptor-gamma gene on metabolic syndrome. 16314192 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE This Review will focus on the role of PPARgamma in human physiology, with specific reference to clinical pharmacological studies, and analysis of PPARG gene variants in the abnormal lipid and carbohydrate metabolism of the metabolic syndrome. 16511590 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome. 16916989 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Angiotensin II receptor blockers with the ability to selectively modulate activity of peroxisome proliferator-activated receptor-gamma and expression of genes in these fat metabolism pathways may represent useful prototypes for a new class of transcription modulating drugs aimed at treating patients with hypertension and the metabolic syndrome. 17339535 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease LHGDN Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes: effect of the PPARgamma Pro12Ala polymorphism: the FinnDiane Study. 17351273 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Mutations in PPARG are associated with insulin resistance and familial partial lipodystrophy, a disease characterized by altered distribution of sc fat and symptoms of the metabolic syndrome. 17356052 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Familial partial lipodystrophy caused by mutations in the PPARG gene is characterised by altered distribution of subcutaneous fat, muscular hypertrophy and symptoms of metabolic syndrome. 17766367 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease LHGDN Frequency of the Pro 12Ala gene polymorphism PPARg2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40-65 years in Ukrainian population. 18268966 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The frequencies of 2 common polymorphisms of the PPARgamma gene, Pro12Ala single nucleotide polymorphism (SNP) in exon B and C161T SNP in exon 6, were investigated in 792 subjects and the correlations between the different genotypes, IR and metabolic syndrome (MS) were analyzed. 18362424 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The most prevalent human PPARgamma gene variant, Ala12, is associated with postprandial hypertriglyceridemia in patients with metabolic syndrome, although the mechanism whereby this polymorphism affects lipid homeostasis remains to be fully determined. 18424599 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components. 18959602 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population. 19237017 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in obesity and in some components of the metabolic syndrome in unselected population. 19534662 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The aim of this study was to evaluate the frequency of Pro12Ala PPARgamma polymorphism and its association with body mass index (BMI) and metabolic syndrome parameters in postmenopausal Polish women. 19609844 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE The genes that encode peroxisome proliferator-activated receptors (PPARs; 3 isotypes PPARalpha, PPARgamma and PPARdelta also known as PPARbeta or PPARbeta/delta), which may serve as transcriptional nodal points and therapeutic targets for metabolic syndromes, were among those affected. 19639232 2009