Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma and its coactivator-1 alpha may be associated with features of the metabolic syndrome in adolescents. 16216916 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in obesity and in some components of the metabolic syndrome in unselected population. 19534662 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE PPARγ ligands such as thiazolidinediones (TZDs) exert insulin sensitizing and anti-inflammatory effects primarily through action on adipocytes, and are thus widely used to treat metabolic syndrome, especially type II diabetes. 21605560 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. 21833030 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. 22168210 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE PPAR-γ was increased in adipose tissue from MS rats. 24819472 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor-γ (PPARγ) is a master regulator of adipogenesis, and alterations in its function are associated with various pathological processes related to metabolic syndrome. 30618832 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE PPARγ can serve as potential target in treatments of metabolic syndrome diseases and/or hypertension. 31184312 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome. 16916989 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Angiotensin II receptor blockers with the ability to selectively modulate activity of peroxisome proliferator-activated receptor-gamma and expression of genes in these fat metabolism pathways may represent useful prototypes for a new class of transcription modulating drugs aimed at treating patients with hypertension and the metabolic syndrome. 17339535 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. 16186413 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population. 19237017 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (<i>PPAR-γ</i>), the fat mass and obesity-associated (<i>FTO</i>), and the melanocortin-4 receptor (<i>MC4R</i>) genes. 29315078 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Collectively, this study establishes a critical role of CRL4B in the regulation of PPARγ stability and insulin sensitivity and suggests that CUL4B could be a potential therapeutic target for combating obesity and metabolic syndromes. 27899484 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. 12161548 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE DBZ is a putative PPARγ agonist that prevents HFD-induced obesity-related metabolic syndrome and reverse gut dysbiosis. 28736228 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Dietary bitter melon seed increases peroxisome proliferator-activated receptor-γ gene expression in adipose tissue, down-regulates the nuclear factor-κB expression, and alleviates the symptoms associated with metabolic syndrome. 21128828 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Drugs also increased GLUT4 and PPARγ protein expression compared with MS control group. 30256492 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Effects of two common polymorphisms of peroxisome proliferator-activated receptor-gamma gene on metabolic syndrome. 16314192 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Familial partial lipodystrophy caused by mutations in the PPARG gene is characterised by altered distribution of subcutaneous fat, muscular hypertrophy and symptoms of metabolic syndrome. 17766367 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Findings from the present study suggested that a sedentary lifestyle and vitamin D deficiency accelerated the occurrence of metabolic syndrome probably by decreasing the expression of nuclear receptor PPARγ. 28336108 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease LHGDN Frequency of the Pro 12Ala gene polymorphism PPARg2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40-65 years in Ukrainian population. 18268966 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Furthermore, galectin-3 might be a potential therapeutic target in metabolic syndromes as a PPARγ regulator. 25343273 2015
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. 19745552 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE However, this evolutionary adaptation to store energy in fat, which can be released under the form of fatty acids, potent PPARgamma agonists, has become a disadvantage in today's affluent society as it results in numerous metabolic imbalances, collectively known as the metabolic syndrome. 15667578 2005