Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE We investigated the synergism between variants at the PPARγ locus (C161T and Pro12Ala polymorphisms) with insulin resistance on metabolic syndrome (MS). 24243083 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 were associated with MS in Kazakh subjects. 25366759 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The influences of PPARγ (C1431T and Pro12Ala) and RBP4 (-803GA) polymorphisms on metabolic syndrome in HIV-infected patients receiving anti-retroviral therapy were examined in this study. 23145084 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes. 21877956 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The present study suggested that the variant genotypes in PPAR-γ gene could increase the risk of MetS; however, genotypes in RXR-α gene could decrease the risk of MetS in a Chinese Han population. 22475777 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Increased expression of interleukin-1 receptor antagonist (IL-1Ra) and IL-10, a trend for higher IL-1β, and no change in peroxisome proliferator-activated receptor-γ (PPARγ) was found in EAT from MS or type 2 diabetes.Only PPARγ mRNA was reduced in SAT. 21289232 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Dietary bitter melon seed increases peroxisome proliferator-activated receptor-γ gene expression in adipose tissue, down-regulates the nuclear factor-κB expression, and alleviates the symptoms associated with metabolic syndrome. 21128828 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE PPARγ ligands such as thiazolidinediones (TZDs) exert insulin sensitizing and anti-inflammatory effects primarily through action on adipocytes, and are thus widely used to treat metabolic syndrome, especially type II diabetes. 21605560 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. 21833030 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Two-way ANCOVA with adjustment for age as a covariate indicated that fitness and the CC genotype of C1431T in the PPARγ2 gene interacted to produce a significant effect on MetS risk in younger men and that the risk of MetS in the CC genotype group with low cardiorespiratory fitness was significantly higher than that in the corresponding CT+TT genotypes or in the high fitness groups. 21156835 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE PPARγ Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. 22168210 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population. 19805902 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved in obesity and in some components of the metabolic syndrome in unselected population. 19534662 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE The genes that encode peroxisome proliferator-activated receptors (PPARs; 3 isotypes PPARalpha, PPARgamma and PPARdelta also known as PPARbeta or PPARbeta/delta), which may serve as transcriptional nodal points and therapeutic targets for metabolic syndromes, were among those affected. 19639232 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The aim of this study was to evaluate the frequency of Pro12Ala PPARgamma polymorphism and its association with body mass index (BMI) and metabolic syndrome parameters in postmenopausal Polish women. 19609844 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population. 19237017 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for MetS and IR. 19745552 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The frequencies of 2 common polymorphisms of the PPARgamma gene, Pro12Ala single nucleotide polymorphism (SNP) in exon B and C161T SNP in exon 6, were investigated in 792 subjects and the correlations between the different genotypes, IR and metabolic syndrome (MS) were analyzed. 18362424 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Our data do not support a major role for the Pro12Ala variant of the PPARG gene in MetS and its individual components. 18959602 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE The most prevalent human PPARgamma gene variant, Ala12, is associated with postprandial hypertriglyceridemia in patients with metabolic syndrome, although the mechanism whereby this polymorphism affects lipid homeostasis remains to be fully determined. 18424599 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease LHGDN Frequency of the Pro 12Ala gene polymorphism PPARg2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40-65 years in Ukrainian population. 18268966 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Familial partial lipodystrophy caused by mutations in the PPARG gene is characterised by altered distribution of subcutaneous fat, muscular hypertrophy and symptoms of metabolic syndrome. 17766367 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease LHGDN Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes: effect of the PPARgamma Pro12Ala polymorphism: the FinnDiane Study. 17351273 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 GeneticVariation disease BEFREE Mutations in PPARG are associated with insulin resistance and familial partial lipodystrophy, a disease characterized by altered distribution of sc fat and symptoms of the metabolic syndrome. 17356052 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.300 AlteredExpression disease BEFREE Angiotensin II receptor blockers with the ability to selectively modulate activity of peroxisome proliferator-activated receptor-gamma and expression of genes in these fat metabolism pathways may represent useful prototypes for a new class of transcription modulating drugs aimed at treating patients with hypertension and the metabolic syndrome. 17339535 2007