| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | GeneticVariation | disease | BEFREE | Methylation changes of <i>IGF2/H19</i> affect growth trajectory and nutrient use with risk of metabolic syndrome. | 28916632 | 2017 | ||||
|
0.270 | PosttranslationalModification | disease | BEFREE | Additionally, IGF2 methylation varies as a function of environmental influences and is associated with schizophrenia and MetS. | 24956249 | 2014 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | Some reports also refer to the effect of disturbances in the expression of the insulin-like growth factor (IGF) system on pancreas beta-cell function in humans and IGF-2/ApaI polymorphisms have been associated with obesity and features of the metabolic syndromes. | 19560381 | 2009 | ||||
|
0.270 | Biomarker | disease | RGD | Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids. | 18418699 | 2008 | ||||
|
0.270 | Biomarker | disease | BEFREE | We observed a decreased expression of five metallothioneins, and an increased expression of liver expressed plasminogen activator inhibitor-1 protein and insulin-like growth factor II, which play a prominent role in the development of the metabolic syndrome. | 17658692 | 2007 | ||||
|
0.270 | Biomarker | disease | BEFREE | Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type). | 17560154 | 2007 | ||||
|
0.270 | Biomarker | disease | BEFREE | The IGF2-INS-TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). | 14749349 | 2004 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | Insulin sensitivity decreased in the subjects with IGF2 Apa I GG and the subjects with IGFBP1 Bgl II AA showed an accumulation of abdominal visceral fat and the early symptoms of the metabolic syndrome after long-term caloric surplus. | 11793026 | 2001 |