Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE A 3-SNP GRS and MetRS were generated in the EPIC-Norfolk cohort (n = 20,074) based on 3 SNPs in LPL and APOA5 or the number of Metabolic Syndrome criteria present (maximum 5), respectively. 30910668 2020
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoprotein to supply fatty acids, and its deficiency leads to hypertriglyceridemia, thereby inducing metabolic syndrome (MetSyn). 31234537 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 AlteredExpression disease BEFREE Significant increases were observed in blood pressure, HOMA-IR, leptin, triglycerides, insulin, intra-abdominal fat, and number of fat cells per field (<i>p</i> = 0.001) and in advanced glycosylation products, adipocyte area, LPL, HSL activities and/or expression (<i>p</i> ≤ 0.01) in the MS groups progressively from the third month onward. 31284400 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE Gender-related relation between metabolic syndrome and S447X and HindIII polymorphisms of lipoprotein lipase gene in northern Iran. 31034941 2019
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE Mutations in the lipoprotein lipase gene causing decreased lipoprotein lipase activity are associated with surrogate markers of insulin resistance and the metabolic syndrome in humans. 28502509 2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS. 30381540 2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 PosttranslationalModification disease BEFREE The aim of this study was to analyze the level of DNA methylation of several lipoprotein lipase (LPL)-promoter-CpG dinucleotides in a CpG island region and relate this to the gene and protein expression levels in human visceral adipose tissue (VAT) from individuals with and without MetS. 29046332 2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease GWASCAT Multiple genotype-phenotype association study reveals intronic variant pair on SIDT2 associated with metabolic syndrome in a Korean population. 30382898 2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE The LPL polymorphism contributed to the severity of coronary disease in patients with MS and recent ACS. 29412239 2018
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. 27827461 2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Therapeutic disease RGD Gly in MS rats decreased body weight, intra-abdominal adipose tissue, adipocyte hypertrophy, blood pressure, triglycerides, insulin, HOMA-IR index, leptin, total fatty acids, non-esterified fatty acids and LPL activity. 26996629 2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE This study investigated the relationship between two common LPL variants and the presence of MetS and its individual components. 27676127 2016
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE Finally, we replicated the LPL and CETP loci previously found to be associated with MetS in Europeans. 26507551 2015
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features. 26370976 2015
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE A novel African American-specific variant, rs12721054/APOC1, and rs10096633/LPL are associated with ≥3 MetS components. 25023634 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). 24200052 2014
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE LPL mass was significantly lower in patients with PvuII and HindIII mutant alleles (P2 and H2) and decreased as the number of MetSyn components increased in all PvuII and HindIII haplotypes. 23927945 2013
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease GWASCAT Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease GWASDB Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. 22399527 2012
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE This was the first study this kind to show an association between LPL and large VLDL particle size within the MetS, a pattern associated with higher IR. 21854610 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 Biomarker disease BEFREE Plasma fatty acid composition, plasma lipid concentrations and LPL SNPs were determined in 452 subjects with the MetS in the European LIPGENE human study and were repeated in 1754 subjects from the LIPGENE-SU.VI.MAX Study. 21840003 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease GWASDB A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE Logistic regression analysis after adjustment for age, sex, adiponectin and S447X polymorphism demonstrated that LPL mass was inversely associated with CHD in men and both genders (p=0.02), with hypertension confined to women (p=0.04) and with MS likelihood in both genders combined and women [odds ratio 1.51 (95% CI 1.14-2.00) for halving the likelihood]. 19191728 2009
Entrez Id: 4023
Gene Symbol: LPL
LPL
0.400 GeneticVariation disease BEFREE We assessed lipid levels and the frequencies of the cholesteryl ester transfer protein (CETP) Taq-1 B, lipoprotein lipase (LPL)S447X, -93 T/G, apolipoprotein B (APO B) 96bp ins/del, lipoprotein(a) (LP[a]) pentanucleotide repeat, and apolipoprotein E (APO) E epsilon 2/3/4 polymorphisms in relation to the metabolic syndrome using both National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) definitions. 19642912 2009