| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of MetS as well as between OPG and NAFLD remains uncertain. | 29785076 | 2018 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The purpose of this study was to determine the effect of resistance exercise on serum OPG levels and insulin resistance in middle-aged women with metabolic syndrome. | 30582576 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Osteoprotegerin plays an important role in the development of arteriosclerosis, and the effect of osteoprotegerin on intima media thickness strongly depends on the extent of the arteriosclerotic changes that occur in metabolic syndrome. | 29077157 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our study demonstrates that compared to dietary SFAs, MUFAs from olive oil protect against atherosclerosis by interfering with vascular calcification via the RANKL/RANK/OPG system in the setting of MetS. | 28276564 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | In addition to the roles of OPG in bone metabolism, it has been reported to be associated with a high cardiovascular risk in patients with metabolic syndrome. | 28849089 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Patients with the MS (n=60) had higher OPG than patients without (n=178) (p<0.05). | 25218813 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | In this review, we analyse the role of OPG in diabetic patients and its links with the most relevant associated diseases such as atherosclerosis, hypertension, endothelial dysfunction and diabetic nephropathy, as well as its connection with related pathologies as fibrosis, obesity and metabolic syndrome. | 21568931 | 2011 |