Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE Effects of TNF-α inhibitors in patients with psoriasis and metabolic syndrome: a preliminary study. 28421729 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE In this study we aim to investigate the role of alternative splicing in pathways leading to metabolic syndromes mediated by TNF-α. 31476685 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE TNF-α: decreased in healthy, fatty liver, IBD and hepatic cirrhosis, no change in diabetes, metabolic syndrome (MS) + PCOS (polycystic ovary syndrome) and arthritis. 31060892 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE Recent studies have shown that pentraxin-3 (PTX-3), osteoprogerin (OPG), and tumor necrosis factor-alpha (TNF-α) are key factors in MetS pathophysiology, but evidence for endorsing their clinical use is currently unclear and insufficient. 31560233 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE A statistically significant decrease in the concentration of TNF-α after treatment was also found (baseline, 5.3 ± 1.4 vs. post-treatment, 3.5 ± 1.3, <i>p</i> < 0.05).Our findings suggest that the consumption of the dry fruit of <i>Sechium edule</i> has an antioxidant and anti-inflammatory effect in older adults with metabolic syndrome. 31137783 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE α<sub>1</sub>-adrenoceptor blockade, endothelial protection, TNF-α suppressing and antioxidant activity together with favorable pharmacokinetic parameters determines high efficacy of MH-76, leading to the effective improvement of hemodynamic and metabolic disturbances in metabolic syndrome. 31133498 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE This study aimed to evaluate the association between serum vitamin D levels and nonalcoholic fatty liver disease (NAFLD) parameters, such as metabolic syndrome (MS), inflammatory cytokines (tumor necrosis factor, high sensitive C-reactive protein) and adipokines (adiponectin, leptin). 31311491 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE This meta-analysis showed beneficial effects of RS on improving FPG, insulin, HbA1c, total cholesterol, LDL-cholesterol and TNF-α levels in patients with MetS and related disorders, but it did not affect HOMA-IR, triglycerides, HDL-cholesterol, CRP and IL-6 levels. 31661295 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 GeneticVariation disease BEFREE To identify genetic variants in promoter areas of IL-6 -174 G>C and TNF-α -308 G>A in metabolic syndrome (Met S) and controls and associate them with Met S and serum cytokine levels.It was a cross-sectional study, including 224 cases of Met S and 200 controls. 30635365 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE Circulating C1q/TNF-related protein isoform 15 is a marker for the presence of metabolic syndrome. 30303269 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE While, quercetin supplementation did not significantly affect triglycerides (TG) (SMD = -0.32; 95% CI, -0.68, 0.04; p = 0.08; I<sup>2</sup>: 84.8), HDL-cholesterol (SMD = 0.20; 95% CI, -0.20, 0.24; p = 0.84; I<sup>2</sup>: 70.6), interleukin 6 (IL-6) (SMD = -0.69; 95% CI, -1.69, 0.31; p = 0.17; I<sup>2</sup>: 94.5) and tumor necrosis factor-alpha (TNF-α) levels (SMD = -0.06; 95% CI, -0.25, 0.14; p = 0.58; I<sup>2</sup>: 35.6) Conclusions: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced total-cholesterol, LDL-cholesterol, and CRP levels, yet did not affect triglycerides, HDL-cholesterol, IL-6 and TNF-α among patients with MetS and related disorders. 31017459 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 PosttranslationalModification disease BEFREE LPL and TNF DNA methylation values were significantly different in the control-case comparisons, with higher and lower methylation respectively in the MetS group. 30642114 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE Phytochemicals improve the dysbiosis (gut microbiota complication) induced by metabolic syndrome and regulate inflammatory diseases induced by TNF-α production. 31142251 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE TNF-<i>α</i> inhibition may be a potential strategy for the prevention of metabolic syndrome and could play a role in the reduction of cardiovascular risk in RA. 31397188 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE The pooled results using random effects model showed that statin use statistically significantly decreased CRP level (SMD= -0.97; 95% CI, -1.10, -0.85; P < 0.001; I<sup>2</sup>: 95.1%), TNF-α (SMD= -1.88; 95% CI, -2.40, -1.38; P < 0.001; I<sup>2</sup>: 97.2%), IL-6 (SMD= -1.67; 95% CI, -1.98, -1.34; P < 0.001; I<sup>2</sup>: 96.5%), and IL-1 concentrations (SMD= -8.35; 95% CI, -10.49, -6.22; P < 0.001; I<sup>2</sup>: 98.4%) among patients with MetS and related disorders. 30576798 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE Even Short-Term Telmisartan Treatment Ameliorated Insulin Resistance But Had No Influence on Serum Adiponectin and Tumor Necrosis Factor-Alpha Levels in Hypertensive Patients with Metabolic Syndrome. 30688550 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE Serum levels of TGF-β and TNF-α in PE patients with MetS were increased compared to other two groups, while IL-10 levels were significantly reduced. 30614120 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE In patients with rheumatoid arthritis (RA), insulin resistance (IR), a component of the metabolic syndrome, is closely linked to the systemic inflammation induced by proinflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-6. 30418124 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE Patients with both schizophrenia and MetS had significantly higher levels of TNF-alpha than the control subjects (Z = - 4.37, P < 0.01). 30519766 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17) in the sera as well as Gal-3 over TNF-α and IL-17 in feces of UC patients with MetS. 31798282 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE To investigate the levels of the proinflammatory cytokines tumor necrosis factor α (TNF-α), interleukin 23 (IL-23) and IL-17 in patients with psoriasis and psoriatic arthritis with concomitant metabolic syndrome. 30858782 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE The pooled results using random effects model indicated that melatonin supplementation significantly reduced C-reactive protein (CRP) (SMD = - 1.80; 95% CI - 3.27, - 0.32; P = 0.01; I<sup>2</sup>: 95.2) and interleukin 6 (IL-6) concentrations (SMD = - 2.02; 95% CI - 3.57, - 0.47; P = 0.01; I<sup>2</sup>: 91.2) among patients with MetS and related disorders; however, it did not affect tumor necrosis factor-α (TNF-α) concentrations (SMD = - 1.87; 95% CI - 3.81, 0.07; P = 0.05; I<sup>2</sup>: 94.4). 29907916 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE Higher levels of IL-17, IL-23 and TNF-α were observed in patients with metabolic syndrome accompanying psoriasis. 30206447 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE In all youth, MetS severity was significantly associated with body fat %, ADP, interleukin-6 (IL-6) and TNF-α and also with CRP in PWS, but associations became non-significant for CRP and IL-6 when controlling for body fat %. 29975666 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE These data partly implicate tPVAT NOX2 and TNFα in mediating the vascular pathology of metabolic syndrome. 29349831 2018