Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Alzheimer's disease is a neurodegenerative disorder characterized by extracellular deposition of amyloid-β (Aβ) peptide and hyperphosphorylation of Tau protein, which ultimately leads to the formation of intracellular neurofibrillary tangles and cell death. 31795012 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Self-assembly of α-synuclein (α-Syn) is linked with a variety of neurodegenerative diseases collectively called as α-synucleiopathies. 31505208 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Encoding the Sequence of Specific Autoantibodies Against beta-Amyloid and alpha-Synuclein in Neurodegenerative Diseases. 31507618 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Multiple systems atrophy (MSA) is a rare neurodegenerative disorder characterized by the accumulation of α-synuclein in glial cells and neurodegeneration in the striatum, substantia nigra, and cerebellum. 30968343 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17. 30905766 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Parkinson's disease (PD) is a common neurodegenerative disease typically associated with the accumulation of α-synuclein. 30905782 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Parkinson's disease (PD) is a well-known neurodegenerative disorder characterized by dopaminergic (DA) neuron loss and α-synuclein aggregation. 30551452 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Hyperphosphorylation of the microtubule-associated protein tau and its resultant aggregation into neurofibrillary tangles (NFT) is a pathological characteristic of neurodegenerative disorders known as tauopathies. 31780921 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 AlteredExpression group BEFREE Though α-synuclein is expressed predominantly in neurons, α-synuclein aggregates in astrocytes are a common feature in these neurodegenerative diseases. 30798354 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Tauopathies are a class of neurodegenerative diseases characterized by the presence of pathological intracellular deposits of Tau proteins. 31522011 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Alzheimer's Disease (AD) is an age-dependent neurodegenerative disorder, the most common type of dementia that is clinically characterized by the presence of beta-amyloid (Aβ) extracellularly and intraneuronal tau protein tangles that eventually leads to the onset of memory and cognition impairment, development of psychiatric symptoms and behavioral disorders that affect basic daily activities. 31642777 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation group BEFREE Mutations in the microtubule-associated protein tau (MAPT) underlie multiple neurodegenerative disorders, yet the pathophysiological mechanisms are unclear. 30590647 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE SNCB is thought to function as an antagonist of α-synuclein in neurodegenerative diseases, but the exact role of SNCB remains unclear. 31128101 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Human tauopathies are neurodegenerative diseases with accumulation of abnormally phosphorylated and aggregated tau proteins forming neurofibrillary tangles. 31306814 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 GeneticVariation group BEFREE In addition, Tau gene mutations, aberrant mRNA splicing and abnormal post-translational modifications, such as hyperphosphorylation, lead to formation of pathological, insoluble Tau aggregates that are a hallmark of neurodegenerative diseases, collectively known as tauopathies. 30550860 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE α-Synuclein (α-syn) represents the main component of the amyloid aggregates present in Parkinson's disease and other neurodegenerative disorders, collectively named synucleinopathies. 31140178 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. 31436053 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Parkinson's disease (PD) is the second most common neurodegenerative disorder and a central role for α-synuclein (αSyn; SNCA) in disease aetiology has been proposed based on genetics and neuropathology. 30753527 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). 31555088 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Abnormal folding and aggregation of the microtubule-associated protein, tau, is a hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD). 31524157 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE Neurodegenerative diseases such as Alzheimer's disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain. 30874605 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker group BEFREE Recent research evidence is now emerging in support of its therapeutic potential for different pathologies including neurodegenerative diseases.Herein, the <i>C. sativus</i> L. natural compounds <i>trans</i>-crocin 4 and <i>trans</i>-crocetin were selected for in depth molecular characterization of their potentially protective effects against Alzheimer's Disease (AD), utilizing two AD neuronal cell culture models (SH-SY5Y overexpressing APP and PC12 expressing hyperphosphorylated tau). 30971876 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker group BEFREE We hypothesized that intermediate C9orf72 repeats are a genetic risk factor for corticobasal degeneration (CBD), a neurodegenerative disease that can be clinically similar to Parkinson's but has distinct tau protein pathology. 31327044 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.400 Biomarker group BEFREE α-Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α-synuclein inclusions in neurons and glia. 31267577 2019
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 AlteredExpression group BEFREE Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. 30907729 2019