Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542). 22737229 2012
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B. 23449268 2013
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 AlteredExpression disease BEFREE Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. 21346778 2011
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population. 28119119 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE To identify host genetic factors that are associated with chronic hepatitis B (CHB) susceptibility, we previously conducted a two-stage genome-wide association study (GWAS) and identified the association of HLA-DP variants with CHB in Asians; however, only 179 cases and 934 controls were genotyped using genome-wide single nucleotide polymorphism (SNP) arrays. 21750111 2011
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE To investigate the association of HLA-DP polymorphisms with response to peginterferon (PEG-IFN) in Caucasian chronic hepatitis B (CHB) patients. 25109699 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: case-control study and meta-analysis. 22543033 2012
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Previous studies showed that single nucleotide polymorphisms (SNPs) in the HLA-DP, TCF19 and EHMT2 genes may affect the chronic hepatitis B (CHB). 24465836 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Some variants of the HLA-DP locus (HLA-DPA1 A allele and HLA-DPB1) protect against progression of chronic hepatitis B infection. 24654629 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. 26449183 2015
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE This study aimed to investigate the association of two single nucleotide polymorphism (SNPs), one in the HLA-DPB1 (rs9277535) and one in the HLA-DQB2 (rs7453920), with chronic hepatitis B infection in a southern Brazilian sample. 28613373 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 AlteredExpression disease BEFREE HLA-DP and γ-interferon receptor-2 gene variants and their association with viral hepatitis activity in chronic hepatitis B infection. 23980639 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE However, whether there exists an association between HLA-DP variants and the progression of CHBVI remains to be determined. 24846544 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. 19349983 2009
Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
0.440 GeneticVariation disease BEFREE Some variants of the HLA-DP locus (HLA-DPA1 A allele and HLA-DPB1) protect against progression of chronic hepatitis B infection. 24654629 2014
Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
0.440 GeneticVariation disease BEFREE We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542). 22737229 2012
Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
0.440 GeneticVariation disease BEFREE Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. 19349983 2009
Entrez Id: 3113
Gene Symbol: HLA-DPA1
HLA-DPA1
0.440 AlteredExpression disease BEFREE Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. 21346778 2011
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE Efficacy and safety of interferon alpha-2b versus pegylated interferon alpha-2a monotherapy in children with chronic hepatitis B: a real-life cohort study from Shanghai, China. 31487005 2019
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE The outcome of 31 children with HB e antigen (HBeAg)-positive chronic hepatitis who randomly received either no treatment (n = 9) or 10 million units of interferon alpha-2b/m2, alone (n = 13) or after prednisone priming (n = 9), three times weekly for 1 year was studied. 8852910 1996
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE HBsAg clearance by the addition of a short course of Peg-interferon α-2a represents an important result with clinical and pharmaco-economic implications, considering that nucleos(t)ide analogues therapy in HBeAg negative chronic hepatitis B patients is considered a long-lasting/life-long treatment. 25024631 2014
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 GeneticVariation disease BEFREE Meanwhile, patients with chronic hepatitis B (CHB) were treated with pegylated interferon α-2b for 24-48 weeks. 24636575 2014
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE The effect of peginterferon alpha-2a vs. interferon alpha-2a on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients. 26382279 2016
Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
0.400 Biomarker disease BEFREE The aim of this study was to investigate possible involvement of estrogen receptor α (ESR1) in responding to pegylated interferon alpha-2a (PEG IFNα-2a) therapy in chronic hepatitis B (CHB) patients. 26485345 2016