| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | TGF-β signaling was significantly up-regulated in the advanced fibrosis stage of CH-C. A significant positive correlation was observed between the expression of TGF-β2 and mothers against decapentaplegic homolog 2 (Smad2), Smad2 and Foxo3a, and Foxo3a and Socs3 in the liver of CH-C patients. | 24962339 | 2014 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. | 25132761 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Intrahepatic SOCS1, SOCS3 and SOCS7 mRNA levels do not predict virological response to therapy in chronic hepatitis C. The association between SOCS1, SOCS3 and cirrhosis warrants further study. | 23164156 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We and others have observed that hepatic levels of suppressor of cytokine signaling 3 (SOCS3) are significantly higher in persons with chronic hepatitis C, particularly those who are nonresponders to interferon (IFN) treatment, than in healthy individuals. | 20375166 | 2010 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. | 17881539 | 2008 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Overexpression of the suppressor of cytokine signaling 3 (SOCS3) gene in liver tissue is associated with a poorer treatment outcome in patients with chronic hepatitis C viral genotype 1. | 17668875 | 2007 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C. | 17258724 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. | 16299039 | 2006 |