Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE The impact of COMT polymorphisms on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. 30146088 2019
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders. 29330410 2018
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group PSYGENET Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. 25766270 2015
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. 25766270 2015
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group PSYGENET Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders. 23351565 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group PSYGENET COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders. 23351565 2013
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815 2012
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group PSYGENET Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815 2012
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE COMT and age at onset in mood disorders: a replication and extension study. 21600957 2011
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group PSYGENET We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post-hoc analyses, specifically against bipolar disorder or major depressive disorder. 21438144 2011
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE Catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis and pharmacological treatment of affective disorders. 20531207 2010
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE In several previous biochemical, pharmacological, and genetic studies, the catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of affective disorders. 17522626 2008
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE The COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes. 18828035 2008
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE In the present paper we analysed SERTPR in the onset of mood disorders, along with adverse life events, and other candidate genes: the serotonin receptor 1A (5-HT1A), the dopamine receptor D4 (DRD4) and the catechol-O-methyltransferase (COMT). 16756688 2007
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE COMT variants were not associated with mood disorders in our sample, a trend was observed toward an excess of COMT*A allele in the pooled sample. 16969269 2006
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE We examined the relationship of a common functional polymorphism (Val108/158Met) in the COMT gene, which accounts for four-fold variation in enzyme activity, with 'early-onset' (EO) forms (less than or equal to 25 years) of MD, including patients with major depressive disorder (EO-MDD) and bipolar patients (EO-BPD), in a European multicenter case-control sample. 15583702 2005
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group BEFREE BDNF and COMT polymorphisms: relation to memory phenotypes in young adults with childhood-onset mood disorder. 15626819 2004
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 GeneticVariation group LHGDN Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders. 12782971 2003
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE Our results suggest that MAO-A, COMT, 5-HT2A, DRD2, and DRD4 gene variants are not involved in susceptibility toward different time courses in mood disorders. 11992560 2002
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants. 11992559 2002
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE We conclude that genetic variation that determines high and low activities of COMT does not have a major effect on the vulnerability to affective disorders in our sample. 9270905 1997
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 Biomarker group BEFREE The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse, and attention deficit hyperactivity disorder. 8807664 1996
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.400 AlteredExpression group BEFREE Various statistical analyses yielded no significant differences in lithium measures or COMT activity levels between members diagnosed as having a form of affective disorder and the normal members. 6589966 1984