Exposure to PQ significantly increased total WBC, neutrophil, eosinophil, lymphocyte, and monocyte counts, IL-10, interferon gama (INF-γ), nitrite (NO<sub>2</sub>), and malondialdehyde (MDA) levels, but catalase (CAT), superoxide dismutase (SOD), and thiol levels were decreased (<i>p</i> < 0.05 to <i>p</i> < 0.00).<i>Z. multiflora</i> and dexamethasone treatment significantly improved all behavioral as well as lung changes induced by inhaled PQ (<i>p</i> < 0.05 to <i>p</i> < 0.01).<b>Conclusion:</b><i>Z. multiflora</i> treatment improved learning and memory impairment as well as lung inflammation and oxidative stress induced by inhaled PQ.