Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 CausalMutation disease CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Thus, changes in gene copy number or level of expression of HER-I or c-myc DNA sequences may play an important role in the pathogenesis of esophageal cancer in this high-risk region. 2459070 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Our results suggest that enhanced transcription of the epidermal growth factor receptor gene is associated with the development of some esophageal cancers. 3044581 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE The int-2 and erbB genes are amplified more frequently than any other genes in human esophageal cancer. 9316622 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE To evaluate which molecular biological factors are related to patients' prognosis and recurrence, we checked p53, p16, p21/Waf1, cyclin D1, Ki-67, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), Mdm2, Bcl2, E-cadherin and MRP1/CD9 by means of immunohistochemical analysis in 116 cases of oesophageal cancer (R0). 10376985 1999
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Northern blot analysis revealed a fourfold increase (p < 0.01) in EGF-R mRNA levels in the esophageal cancer samples in comparison with normal tissue samples. 10512940 1999
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE These data suggest that EGF-R and p53 mutation may be used as both outcome predictors and targets for molecular therapy for esophageal cancer. 14695149 2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer. 15213712 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE We review six aspects of the research literature on esophageal cancer: epidemiology and etiology, epidermal growth factor receptor and related growth factor receptors, cell cycle regulatory proteins, transforming growth factor-beta/Smad proteins, mismatch repair genes, and other genes. 15622457 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE While more primary esophageal tumors remain to be screened for the mutations at the tyrosine kinase domain of EGFR, current observation implies that gefitinib may be worth further investigation for treatment of esophageal cancers. 16357520 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE The selection of esophageal cancer patients for future studies with EGFR-TKIs based on the level of EGFR expression in their tumors or SCC histology should be considered. 16575012 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Mutations of EGFR were identified in two esophageal cancers (11.7%), three cases of Barrett's esophagus (14.2%), and two pancreatic cancers (3.6%). 16857803 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations. 17142003 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Gene-gene interaction of EGFR 497Arg>Lys and EGF +61A>G polymorphisms enhanced risk for EC, indicating additive effects. 18773861 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines. 21207425 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human The EGFR CA repeat genetic polymorphism may act as a valuable molecular predictor of clinical outcome of esophageal cancer after CCRT and esophagectomy, especially in those with good response to CCRT. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE The EGFR CA repeat genetic polymorphism may act as a valuable molecular predictor of clinical outcome of esophageal cancer after CCRT and esophagectomy, especially in those with good response to CCRT. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human Targeting the human EGFR family in esophagogastric cancer. 21468131 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE We evaluated the antitumor effects of lapatinib, a dual tyrosine kinase inhibitor which simultaneously inhibits EGFR and HER2, 5-fluorouracil (5-Fu) alone and in combination on esophageal cancer cells. 22293713 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE In this report, the effect of PYM on EGFR expression in human esophageal cancer cells and the therapeutic efficacy of the combination of PYM and cetuximab on esophageal cancer xenograft were investigated. 22311160 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Over-expression of epidermal growth factor receptor in esophageal cancer is associated with poor prognosis. 22555809 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE We report the outcome in a series of esophageal cancer patients treated at our center and the results of a retrospective analysis of epidermal growth factor receptor (EGFR) expression and EGFR/HER2 gene copy numbers taken as possible prognostic and predictive factors. 23052161 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 PosttranslationalModification disease BEFREE Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells. 23174948 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer. 23377570 2014