Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Oleuropein inhibits EC tumorigenesis through hypoxic suppression of BTG3 mRNA, supporting the clinical application of oleuropein, and HIF1α and BTG3 mRNA as potential molecular targets in treatment against EC. | 30702111 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Furthermore, there was markedly increased expression of HIF-1α and plasma OPN levels in FaDu and EC109 xenografts compared with A549. | 29616117 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The expression of hypoxia inducible factor 1α (HIF1α) and pyruvate kinase M2 (PKM2) in esophageal cancer tissues and cells was detected by immunohistochemistry and Western blot. | 29290767 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | To determine if HIF‑1α modulates autophagy and the underlying molecular mechanisms regulating this process, the human esophageal cancer EC109 and IMR90 human diploid fibroblast cell lines were exposed to normoxic or hypoxic conditions and the expression levels of various proteins subsequently examined. | 28627618 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | The PI3K/AKT pathway and HIF-1α are both involved in the process of glycolysis in esophageal cancer cells. | 27239113 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Thus, an HIF-1α inhibitor is viewed as a therapeutic target in treating oesophageal cancer. | 20977428 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | The epithelial-mesenchymal transition (EMT) induced by VHL/HIF-1alpha-TGF-beta1 pathway might be the underlying mechanism responsible to the more aggressive tumor growth in UCP-positive esophageal cancer. | 19083192 | 2009 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Whether HIF-1alpha mRNA or protein expression is associated with histomorphological response or prognosis following neoadjuvant chemoradiation and surgery in resectable, locally-advanced esophageal cancer was analyzed. | 17201171 | 2007 |