Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 GeneticVariation disease BEFREE Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer. 30768848 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 Biomarker disease BEFREE NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1α axis in thyroid carcinomas. 30367082 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 AlteredExpression disease BEFREE Human thyroid cancer cell line follicular thyroid carcinoma (FTC) 133 was endowed with aggressiveness by HIF-1α or β-catenin overexpression. 27840971 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 AlteredExpression disease BEFREE Expression of HIF-1α and HIF-2α as well as vitamin C content was analyzed in thyroid lesions and cultured thyroid carcinoma cell lines (FTC-133 and 8305c) treated with hypoxia-mimetic agent (cobalt chloride) and ascorbic acid. 29084538 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 Biomarker disease BEFREE Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effective therapeutic strategy for thyroid cancer that is refractory to conventional treatments. 25862859 2015
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 Biomarker disease CTD_human HIF-1 alpha was not detectable in normal tissue but was expressed in thyroid carcinomas. 19808899 2010
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 AlteredExpression disease BEFREE HIF-1 alpha was not detectable in normal tissue but was expressed in thyroid carcinomas. 19808899 2010
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.370 Biomarker disease BEFREE These data indicate that IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha and provide the framework for clinical use of small-molecule inhibitors, including geldanamycin analogs, to abrogate proangiogenic cascades in thyroid cancer. 14602779 2003