Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 GeneticVariation disease BEFREE STAG2 is recurrently, mutated in Ewing's Sarcoma, bladder cancer, and glioblastoma, and is one of only ten genes known to be recurrently mutated in over four distinct tissue types of human cancer RECENT FINDINGS: The cohesin complex, a multiprotein ring, is canonically known to align and stabilize replicated chromosomes prior to cell division. 29278534 2018
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 Biomarker disease BEFREE STAG1 inactivation inhibits the proliferation of STAG2 mutated but not wild-type bladder cancer and Ewing sarcoma cell lines. 28691904 2017
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 GeneticVariation disease BEFREE Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. 25223734 2014
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 AlteredExpression disease BEFREE However, we discovered that loss of STAG2 expression occurs in 15% of tumors and is associated with metastatic disease, suggesting a potential genetic vulnerability in Ewing sarcoma. 25186949 2014
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 AlteredExpression disease BEFREE STAG2 encodes a subunit of the cohesion complex that participates in mitotic chromatid separation and was recently found to show low expression and inactivating mutations in Ewing's sarcoma, melanoma and glioblastoma.In the childhood tumor neuroblastoma (NB) segmental chromosomal alterations are associated with poor prognosis whereas tumors displaying whole chromosome gains and losses have a much better prognosis. 24088605 2013
Entrez Id: 10735
Gene Symbol: STAG2
STAG2
0.350 CausalMutation disease CGI