Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE We dispute whether the detection of EWSR1-FEV mandates one to diagnose the patient's tumor as a member of the Ewing sarcoma family. 31831298 2020
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Conversely, treatment with the FAK inhibitor Y15 enhanced caspase-mediated apoptosis and EwS cell migration, independent from the respective EWSR1-ETS fusion type, mimicking an anoikis-like phenotype and paralleling the effects of FAK siRNA knockdown. 31811703 2020
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Tumors had a similar morphologic appearance and immunophenotype as ES with more common EWSR1-ETS fusions. 31756779 2020
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Ewing sarcoma (ES) family of tumors includes bone and soft tissue tumors that are often characterized by a specific translocation between chromosome 11 and 22, resulting in the EWS-FLI1 fusion gene. 31275859 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE EWS-FLI1, the oncogenic driver of Ewing sarcoma, regulated LDH A (LDHA) expression. 31431459 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Ewing Sarcoma (ES) is characterized by recurrent translocations between EWSR1 and members of the ETS family of transcription factors. 31550266 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 AlteredExpression disease BEFREE Through integrative analysis, we identify MEIS1 as a super-enhancer-driven oncogene, which co-operates with EWS-FLI1 in transcriptional regulation, and plays a key pro-survival role in Ewing sarcoma. 30496486 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Emerging studies of Ewing sarcoma have demonstrated EWS-FLI1-driven chromatin remodeling as a key aspect of tumorigenicity. 31207107 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 AlteredExpression disease BEFREE We found that EWS-FLI1 increases BCL-2 expression; however, inhibition of BCL-2 alone by venetoclax is insufficient to sensitize Ewing sarcoma cells to olaparib, revealing a dual necessity for BCL-2 and BCL-X<sub>L</sub> in Ewing sarcoma survival. 30348635 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor. 30470587 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Ewing sarcoma is characterized by a pathognomonic chromosomal translocation that generates the EWSR1-FLI1 chimeric transcription factor. 31036566 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE This interaction has functional consequences in Ewing sarcoma (ES), childhood and adolescence bone malignancies driven by fusions between EWSR1 and FLI1. 31577941 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE These findings show that MSCs from anatomically distinct sites are differentially susceptible to EWS-FLI1-induced transformation, supporting the premise that the dominant presentation of Ewing sarcoma in pelvic and stylopod bones is attributable to anatomically-defined differences in MSCs. 30845695 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE EWSR1 (Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1) gene is ubiquitously expressed in most cell types, indicating it has diverse roles in various cellular processes and organ development. 30481590 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Despite these similarities, Ewing-like sarcomas lack the pathognomonic molecular hallmark of Ewing sarcoma: A translocation between a gene of the RNA-binding TET family (EWSR1 or FUS) with a gene of the ETS-transcription family ( FLI1, ERG, ETV1, ETV4, or FEV). 30257034 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap with Ewing sarcoma (ES), myoepithelial tumors, and extraskeletal myxoid chondrosarcoma has emerged. 30994538 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Our findings illustrate that modulation of the alternative splicing of <i>EWS-FLI1</i> pre-mRNA is a novel strategy for future therapeutics against the <i>EWSR1</i> exon 8 containing fusion oncogenes present in a third of Ewing sarcoma. 31511320 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE We have identified a direct connection between the EWS-FLI1 protein and ARID1A isoform protein variant ARID1A-L. We demonstrate here that ARID1A-L is critical for ES maintenance and supports oncogenic transformation. 31392992 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Our findings not only provide novel insights into the importance of the N-terminal EWSR1 domain for regulation of fusion protein stability, but also indicate that inhibition of deubiquitinating enzyme(s) might constitute a novel therapeutic strategy in treatment of Ewing sarcoma. 30700749 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Certain bone and soft tissue (BST) tumours harbour a chromosomal translocation [t(6;22)(p21;q12)], which fuses the Ewing's sarcoma (EWS) gene at 22q12 with the octamer-binding transcription factor 4 (Oct-4) gene at 6p21, resulting in the chimeric EWS-Oct-4 protein that possesses high transactivation ability. 31155838 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE PET-CT imaging features that differentiate between positive and negative EWSR1 translocation in Ewing sarcoma. 31107830 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Next, the Ewing sarcoma tumour is found to have EWSR1 (exon 10)-FLI1 (exon 8) translocation based on NGS. 30819134 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Inhibitors of the bromodomain and extra-terminal domain (BET) family proteins modulate EWS-FLI1 activities in Ewing sarcoma. 30926641 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 GeneticVariation disease BEFREE Results were compared to methylation data of 30 EwS with various EWSR1-ETS fusions and one EwS with FUS-ERG fusion, 16 URCS with CIC rearrangement and 10 URCS with BCOR alteration and a total of 81 EWSR1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas. 30895378 2019
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.700 Biomarker disease BEFREE Our previous in silico drug screening identified entinostat as a drug hit that was predicted to reverse the ES disease signatures and EWS-FLI1-mediated gene signatures. 31025088 2019