Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | The survival analysis revealed that EZH2 is associated with a poor prognosis in patients with ES. | 31788075 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Here we report that pharmacological inhibition of Enhancer of Zeste Homolog 2 (EZH2) at doses reducing H3K27 trimethylation, but not cell viability, selectively and reversibly induces G<sub>D2</sub> surface expression in Ewing sarcoma cells. | 30879952 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The polycomb proteins BMI-1 and EZH2 are highly overexpressed by Ewing sarcoma (ES), a tumor of stem cell origin that is driven by EWS-ETS fusion oncogenes, most commonly EWS-FLI1. | 25625846 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | Inhibition of β-catenin, poly (ADP-ribose) polymerase 1 (PARP1), or enhancer of zeste homolog 2 (EZH2) suppressed cell growth in a murine model of Ewing's sarcoma, suggesting the utility of the current system as a preclinical model. | 24911143 | 2014 | ||||
|
0.070 | Biomarker | disease | BEFREE | These results clearly identify the ET-derived antigens, EZH2(666) and CHM1(319), as suitable targets for protective allo-restricted human CD8(+) T-cell responses against non-immunogenic ET and may benefit new therapeutic strategies in ET patients treated with allogeneic stem cell transplantation. | 21407224 | 2011 | ||||
|
0.070 | Biomarker | disease | BEFREE | Downregulation of EZH2 by RNA interference suppressed tumor development and metastasis in vivo and microarray analysis of EZH2 knock down revealed an EZH2-maintained, undifferentiated, reversible phenotype in ET. | 19502792 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | Among relevant candidate transcripts induced by EWS-FLI-1 in hMSCs, we found the polycomb group gene EZH2, which we show to play a critical role in Ewing's sarcoma growth. | 18381423 | 2008 |