Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE This is the largest study to date investigating the ES subset with EWSR1/FUS-FEV fusions showing a predilection for extraskeletal sites and aggressive behavior. 31756779 2020
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE Despite these similarities, Ewing-like sarcomas lack the pathognomonic molecular hallmark of Ewing sarcoma: A translocation between a gene of the RNA-binding TET family (EWSR1 or FUS) with a gene of the ETS-transcription family ( FLI1, ERG, ETV1, ETV4, or FEV). 30257034 2019
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE Results were compared to methylation data of 30 EwS with various EWSR1-ETS fusions and one EwS with FUS-ERG fusion, 16 URCS with CIC rearrangement and 10 URCS with BCOR alteration and a total of 81 EWSR1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas. 30895378 2019
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE Further, mouse mesenchymal cells transformed with either the <i>EWS-FLI1</i> or <i>FUS-CHOP</i> rearrangement displayed similar sensitivities to olaparib, whereas the Ewing's sarcoma cell line SK-N-MC had increased olaparib sensitivity. 29313488 2018
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE Eribulin regresses a doxorubicin-resistant Ewing's sarcoma with a FUS-ERG fusion and CDKN2A-deletion in a patient-derived orthotopic xenograft (PDOX) nude mouse model. 28681998 2018
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE In the present study, tumor from a patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss and FUS-ERG fusion was implanted in the right chest wall of nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. 27286459 2016
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE During this investigation we came across a number of ERG-rearranged ES lacking both EWSR1 and FUS abnormalities by FISH. 26690869 2016
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE The inclusions were immunoreactive for FUS, p62, and TATA-binding protein-associated factor 15 (TAF15), but not for phosphorylated tau, transactive response DNA-binding protein of 43 kDa (TDP-43), neurofilament protein, or Ewing sarcoma (EWS). 26227957 2016
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE The strong IHC expression of SATB2 associated with CD99 immunonegativity and the absence of EWSR1 and FUS gene rearrangements in small cell osteosarcoma argues against the existence of a morphologic/genetic continuum with Ewing sarcoma. 25723116 2015
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE FUS is a member of the FET protein family that includes Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 2N (TAF15). 24899704 2014
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE No rearrangement of Ewing sarcoma region 1 (EWSR1) and fused in sarcoma (FUS) genes was observed by fluorescent in situ hybridization. 23079205 2013
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE While ALS-FUS showed only accumulation of FUS, inclusions in FTLD-FUS revealed co-accumulation of all members of the FET protein family, that include FUS, Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 15 (TAF15) suggesting a more complex disturbance of transportin-mediated nuclear import of proteins in FTLD-FUS compared to ALS-FUS. 22842875 2012
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE Cell culture experiments replicated the findings of amyotrophic lateral sclerosis with FUS mutations by confirming the absence of TATA-binding protein-associated factor 15 and Ewing's sarcoma alterations upon expression of mutant fused in sarcoma. 21856723 2011
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV. 17620387 2007
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. 16303180 2006
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 AlteredExpression disease BEFREE These represent the first four cases where FUS, rather than EWS, is rearranged with an ETS-family transcription factor in Ewing's tumors. 12907633 2003
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 GeneticVariation disease BEFREE The FUS (TLS)-ERG chimeric protein associated with t(16;21)(p11;q22) acute myeloid leukemia is structurally similar to the Ewing's sarcoma chimeric transcription factor EWS-ERG. 10523652 1999
Entrez Id: 2521
Gene Symbol: FUS
FUS
0.100 Biomarker disease BEFREE Thus, the TLS/FUS-ERG gene fusion in t(16;21) leukemia is predicted to produce a protein that is very similar to the EWS-ERG chimeric protein responsible for Ewing's sarcoma. 8187069 1994