Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE The Role of C-X-C Chemokine Receptor Type 4 (CXCR4) in Cell Adherence and Spheroid Formation of Human Ewing's Sarcoma Cells under Simulated Microgravity. 31810195 2019
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling. 29776413 2018
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 AlteredExpression disease BEFREE Earlier studies on CXCR4 protein expression in Ewing sarcoma yielded contradictory results when compared to CXCR4 RNA expression studies. 28549419 2017
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE A bivalent promoter contributes to stress-induced plasticity of CXCR4 in Ewing sarcoma. 27528222 2016
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 AlteredExpression disease BEFREE CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients. 26428435 2015
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 AlteredExpression disease BEFREE For validation at protein and functional level, the identified isoforms and normal CXCR4 were cloned into an EYFP tagged vector and ectopically expressed in HEK293T cell line and EWS cell line A673. 26321665 2015
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE To this end, the role of the CXCR4/SDF-1a chemokine axis as a mediator of Ewing sarcoma metastasis was investigated. 24651452 2014
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE The CXCR4 antagonist AMD 3100 was used to disrupt the SDF-1α/CXCR4 axis in vivo in two xenograft Ewing tumor models. 24282276 2014
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 AlteredExpression disease BEFREE Levels of both Wnt5a mRNA and CXCR4 mRNA were significantly higher in specimens from ES patients with metastasis at diagnosis compared with specimens from those without metastasis. 23075330 2012
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE Pairwise analyses showed CXCR4 to correlate with ES metastases, and CXCR4 and CXCR7 to patient survival, but not with several other clinicopathological variables. 20525755 2010
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE We demonstrate that Ewing's sarcoma tumors as well as Ewing's sarcoma cell lines predominantly express the CXCR4 chemokine receptor. 15183454 2004