Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE Expression analyses of miRNA overexpressing glioma cells and 3'-untranslated region luciferase reporter gene assays revealed evidence that these miRNAs post-transcriptionally regulate expression of glioma-relevant genes, including CDK6 (miR-107), EGFR (miR-146b-5p, miR-1287-5p), TERT and SEMA6A (miR-346), all of which are overexpressed in malignant gliomas in situ. 26223576 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 GeneticVariation disease BEFREE The TERT C228T or C250T mutation was found in 33/35 (94 %) of established malignant glioma cell lines and both meningioma cell lines examined. 26960334 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas. 15960600 2005
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 Biomarker disease BEFREE A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. 11605003 2001
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE We used hTERT promoter-modulated expression of the hNIS and human thyroperoxidase (hTPO) genes in an experimental model of radioiodine-based treatment of malignant glioma. 21797672 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE We used the hTERT promoter to drive the expression of the hNIS and human thyroid peroxidase (hTPO) gene as a primary step for testing the effects of radioiodine therapy on malignant glioma. 21801606 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE To establish the hTERT/caspase-8 construct as a novel therapy for malignant gliomas, we need to increase the transcriptional activity of the hTERT promoter in malignant glioma cells. 12067435 2002
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE The hTERT promoter activity in HDFs and MG cell lines was statistically significantly enhanced by HCMV in a dose-dependent manner (mean luciferase activity [arbitrary units] in control HDFs and in HDFs infected with HCMV at multiplicities of infection [MOIs] of 0.1 = 6 and 521, respectively, difference = 515, 95% CI = 178 to 850; mean activity at MOI of 1 and 10 = 8828 and 59,923, respectively; P < .001 comparing control with HCMV-infected cells at all MOIs). 19318640 2009
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 AlteredExpression disease BEFREE Increased levels of hTERT mRNA were observed in two of three hypoxia-treated malignant glioma cell lines. 17699105 2007
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 Biomarker disease CTD_human Epigenetic silencing of telomerase and a non-alkylating agent as a novel therapeutic approach for glioma. 18021753 2008
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.390 Biomarker disease CTD_human Genome-wide association study identifies five susceptibility loci for glioma. 19578367 2009