Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in adult malignant glioma and various other human solid tumor models but not in normal tissues. 11030149 2000
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE It was the aim of our study to determine which genomic alterations in malignant gliomas modulate the sensitivity to chemotherapy or cytotoxic cytokines such as CD95 ligand (CD95L) or Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL). 11146447 2001
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE In the present study we have utilized a panel of seven cell lines derived from human malignant gliomas to characterize molecular pathways through which FasL and TRAIL induce apoptosis in sensitive glioma cells and the mechanisms of resistance in cell lines which survive the death stimuli. 11593384 2001
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE The death ligands CD95L and Apo2L/TRAIL are promising investigational agents for the treatment of malignant glioma. 11770895 2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. 12118245 2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Adenoviral (full-length) Apo2L/TRAIL gene transfer is an ineffective treatment strategy for malignant glioma. 12587790 2003
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE TRAIL and malignant glioma. 15110189 2004
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. 16820965 2006
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Our data indicate that Bcl-2 and Bcl-xL play fundamental roles in TRAIL resistance of malignant glioma and suggest that using TRAIL or agonistic TRAIL receptor antibodies in combination with BH3 mimetics may represent a promising approach to reactivate apoptosis in therapy-resistant high grade gliomas. 17924059 2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 AlteredExpression disease BEFREE To investigate the molecular basis of an experimental combination therapy for malignant gliomas with TRAIL and Troglitazone, we investigated the Troglitazone-induced signaling cascades and the expression of TRAIL receptors and FLIP in malignant gliomas. 19158480 2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Therapeutic disease CTD_human Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. 19229339 2009
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Currently, this Ad-stTRAIL gene therapy is under phase I clinical trial for malignant gliomas. 21822049 2011
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.400 Biomarker disease BEFREE Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. 24436439 2014