Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE In contrast, mutations of phosphatase and tensin homolog (PTEN) and tumor protein 53 (TP53) appeared to be higher in HGG tumors in CC patients than in their AA counterparts. 29599344 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Expression of a Pik3caH1047A was sufficient to generate tumors with oligodendroglial features, but simultaneous loss of PTEN was required for the development of invasive, high-grade glioma. 29718345 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. 28401302 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 PosttranslationalModification disease BEFREE Deletions or mutations of the phosphatase and tensin homolog (PTEN) are frequently observed in malignant glioma and are responsible for progression of the disease. 21617223 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 PosttranslationalModification disease BEFREE The role of the PTEN gene in malignant gliomas. 20358487 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Therefore, the combination of PTEN expression and VEGF knockdown represents an effective gene therapy strategy for malignant gliomas. 21204766 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising in adults, have a substantially lower incidence of genomic alterations of PTEN. 20607350 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts. 17310280 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. 17328268 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules. 16773187 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Our studies suggest that adenovirus-mediated combined TIMP-2 and PTEN gene therapy is possibly useful for anti-invasion therapy of malignant glioma. 15363547 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE In this study, the authors analyzed 20 cases of malignant gliomas obtained in patients living on the east coast of Malaysia to investigate the possibilities of involvement of the PTEN and p16 genes. 15679305 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease CTD_human A novel germline mutation of PTEN associated with brain tumours of multiple lineages. 12085208 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE The objective of this paper was to individuate a prognostic marker in exons 5, 6, 7, and 8 of the PTEN/MMAC1 gene for the high-grade malignant glioma with the most aggressive clinical behavior. 11485247 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE To identify the role of PTEN gene in malignant gliomas. we used PCR-SSCP and direct sequencing methods to examine 44 malignant gliomas comprising 29 cases without and 15 cases with meningeal gliomatosis. 11678426 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. 10435616 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. 9484844 1998