Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Recently published results of trials on elderly patients with malignant gliomas have revived the call for routine MGMT testing for clinical decision making. 23083460 2013
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease CTD_human Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. 16033832 2005
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) may cause resistance to DNA-alkylating drugs commonly used in the treatment of anaplastic oligodendrogliomas and other malignant gliomas. 15455350 2005
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease CTD_human NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. 19901110 2009
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response. 27158275 2016
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Currently, the most efficacious treatment for malignant gliomas is temozolomide; however, gliomas expressing the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) are resistant to this drug. 18089777 2007
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE Our study identified clinicopathological factors related to postoperative seizure in HGGs and found two predictive biomarkers of postoperative seizure: MGMT and EGFR. 26808114 2016
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease CTD_human In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. 16899598 2006
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE According to pathological examination, the tumor was a high-grade glioma that was positive for methylated O-6-methylguanine-DNA methyltransferase promoter. 20354758 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation is not correlated with integrin expression in malignant gliomas: clarifying recent clinical trial results. 29882028 2018
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation in malignant gliomas. 20725792 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE The O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. 22614944 2012
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE MGMT promoter methylation in malignant gliomas: ready for personalized medicine? 19997073 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE These results suggest that the clinical therapeutic efficacy of TMZ might be improved by a combination with IFN-beta in malignant gliomas unmethylated at the MGMT gene. 19513561 2009
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene is a predictive marker for the response to chemotherapy with alkylating agents (e.g., temozolomide) in malignant gliomas. 18795231 2009
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE The MGMT promoter methylation status of malignant gliomas can be reliably determined from small-sized stereotactic biopsies. 17691113 2007
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE LOH of 1p in the heterogeneous population of malignant gliomas may be one of the important factors besides MGMT methylation that predict better outcome in patients treated with TMZ. 17721049 2007
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE We investigated the impact of MGMT methylation and expression on survival of children with high-grade glioma (HGG) registered into the German HIT-GBM database receiving temozolomide (TMZ) as part of their treatment (n = 21 relapsed, n = 4 primary). 19856394 2010
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 AlteredExpression disease BEFREE Enhanced anti-tumor effect of zoledronic acid combined with temozolomide against human malignant glioma cell expressing O6-methylguanine DNA methyltransferase. 25111384 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 PosttranslationalModification disease BEFREE O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. 21365007 2011
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic adducts from the O6 position of guanine, thereby protecting the genome against guanine : cytosine to adenine : thymine transition and, meanwhile, conferring tumor resistance to many anti-cancer alkylating agents commonly used in the treatment of malignant gliomas. 14570288 2003
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 AlteredExpression disease BEFREE Resistance of malignant gliomas to TMZ can be overcome by synchronizing metronomic TMZ regimen with MGMT expression. 21892781 2012
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Logistic regression analysis showed that Leu84Phe of MGMT gene and pathological grade were independent risk factors for the increase of TMZ resistance in patients with malignant gliomas. 28409559 2017
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. 24160898 2013