Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE We have studied alterations of the p53 gene in 27 patients with malignant gliomas. 8019958 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. 8504413 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Our data indicate that p53 gene mutation predisposes to decreased cell killing via chemotherapy in malignant gliomas. 8682593 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Using immunohistochemical analysis, 4 of 10 confirmed malignant gliomas had over-expression of p53. 8847560 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Because p53-dependent apoptosis mechanisms are involved in the cytotoxic effects of irradiation and chemotherapy, we questioned whether p53 status might be associated with outcome in childhood malignant gliomas. 9000573 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE The p53 tumor-suppressor gene (located on chromosome 17) is frequently associated with the loss of one allele in malignant gliomas, although a large number of malignant gliomas have no p53 mutations. 9507524 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The most common of these is deletion of exons 2-7, resulting in truncation of the extracellular domain (DeltaEGFR or EGFRvIII), which occurs in a large fraction of de novo malignant gliomas (but not in progressive tumors or those lacking p53 function) and enhances tumorigenicity, in part by decreasing apoptosis through up-regulation of Bcl-XL. 9576951 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Loss of wild-type p53 activity is one of the most common molecular abnormalities in human cancers including malignant gliomas. 9760067 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Here, we asked whether alterations in the p53 and RB pathways and the expression of six BCL-2 family proteins predicted acute cytotoxicity and clonogenic cell death induced by BCNU, vincristine, cytarabine, teniposide, doxorubicin, camptothecin or beta-lapachone in 12 human malignant glioma cell lines. 9842975 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Infection with F/K20-Adv carrying the wild-type p53 tumor suppressor gene resulted in an enhanced level of p53 protein expression and an increased incidence of F/K20-Adv in transduction efficiency for malignant glioma, providing promising tools for gene therapy. 9853517 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE It is also suggested that high level of apoptosis in malignant glioma could represent a p53 independent pathway. 9887356 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE In summary, combination either with other chemotherapy drugs, with abrogators of the G2/M checkpoint, with wild-type p53 gene transfer was not a promising approach for a taxol-based combination chemotherapy regimen in malignant glioma. 10453723 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Using the AdCMV.p53 vector we measured the in vitro expression of p53 and the resultant effect upon U251 human malignant glioma cellular proliferation. 10533721 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Combined inactivation of CDKN2A and CDKN2B, i.e., loss of both p16 and p15 as well as p14(ARF), results in disruption of two major growth control pathways involving pRB and p53 in malignant gliomas. 10541865 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The p53 gene is thought to function abnormally in the majority of malignant gliomas, although it has been demonstrated to be mutated in only approximately 30%. 10584846 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Additional analyses revealed that the malignant gliomas with MDM4 amplification and overexpression carried neither mutations in conserved regions of the TP53 gene nor amplification of the MDM2 gene. 10626796 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. 10866285 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE In conclusion, heterogeneity of the cellular subpopulations of malignant glioma in p53 status, variable and insufficient gene delivery to tumor, and adenoviral toxicity to brain at higher doses may be limiting factors to be solved in developing adenovirus-p53 gene therapy for malignant gliomas. 10895975 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The P53 pathway is, therefore, disrupted in 81.8% of malignant gliomas (WHO grades III and IV), either by mutation of the p53 gene (31.8%) or by p14arf deletion (54.5%). 10949938 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8. 11023613 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE To elucidate the involvement of murine-double-minute (mdm)2 gene amplifications and mutations of the tumor suppressor gene p53 in the tumorigenesis of malignant gliomas we analyzed a series of 75 glioblastomas. 11212898 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53. 11223987 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Loss of heterozygosity at 11p15 and p53 alterations in malignant gliomas. 11355148 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. 11605007 2001