Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE The P53 pathway is, therefore, disrupted in 81.8% of malignant gliomas (WHO grades III and IV), either by mutation of the p53 gene (31.8%) or by p14arf deletion (54.5%). 10949938 2000
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 22869205 2012
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Similarly, in human malignant gliomas harbouring IDH1 mutations, we find markedly elevated levels of 2HG. 19935646 2009
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival. 23619925 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. 17328268 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. 9484844 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE The objective of this paper was to individuate a prognostic marker in exons 5, 6, 7, and 8 of the PTEN/MMAC1 gene for the high-grade malignant glioma with the most aggressive clinical behavior. 11485247 2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE Thirty-four to fifty-six percent of malignant gliomas harbor homozygous co-deletions of the INK4a(p16-p14ARF) and INK4b(p15) tumor suppressor genes. 11563632 2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE We have investigated by using quantitative polymerase chain reaction and single-strand conformation polymorphism analysis the structure of exon 2 of CDKN2 in 32 malignant gliomas. 7987825 1994
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE These results suggest that the clinical therapeutic efficacy of TMZ might be improved by a combination with IFN-beta in malignant gliomas unmethylated at the MGMT gene. 19513561 2009
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Isocitrate dehydrogenase 1 gene (IDH1) R132H mutation status was also recently identified as a prognostic factor for malignant gliomas. 24929863 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE LOH of 1p in the heterogeneous population of malignant gliomas may be one of the important factors besides MGMT methylation that predict better outcome in patients treated with TMZ. 17721049 2007
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. 30738431 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH. 20102524 2010
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE We identify miR148a as a novel, G-CIMP-associated miRNA whose methylation is tightly correlated with IDH1 mutation and associated with improved survival in patients with malignant glioma. 25224277 2014
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Logistic regression analysis showed that Leu84Phe of MGMT gene and pathological grade were independent risk factors for the increase of TMZ resistance in patients with malignant gliomas. 28409559 2017
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 GeneticVariation disease BEFREE To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. 24160898 2013
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE • APT signals were significantly higher in IDH-wild type compared to IDH-mutant high-grade glioma. 31175415 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma. 30972500 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Recent investigations of malignant gliomas have identified additional genetic and chromosomal abnormalities which cluster with IDH1 mutations into two distinct subgroups. 25471051 2015
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese patients with malignant gliomas. 24160898 2013
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE IDH1 mutations are common in malignant gliomas in older children, suggesting that a subset of these lesions may be biologically similar to malignant gliomas arising in younger adults and may be associated with a more favorable prognosis. 20725730 2011
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE En bloc resection revealed a high-grade glioma with sarcomatous components that was immunoreactive for the R132H variant of IDH1 by antibody. 27153165 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Of 158 tumors with sufficient tissue, 110 (70 %) showed nuclear cMYC immunopositivity--most frequent (95 %, χ(2) p = 0.0248) and intense (mean 1.33, ANOVA p = 0.0179) in anaplastic astrocytomas versus glioblastomas (63 %) or low grade gliomas (74 %). cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. 23934175 2013