Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The most common of these is deletion of exons 2-7, resulting in truncation of the extracellular domain (DeltaEGFR or EGFRvIII), which occurs in a large fraction of de novo malignant gliomas (but not in progressive tumors or those lacking p53 function) and enhances tumorigenicity, in part by decreasing apoptosis through up-regulation of Bcl-XL. 9576951 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Because p53-dependent apoptosis mechanisms are involved in the cytotoxic effects of irradiation and chemotherapy, we questioned whether p53 status might be associated with outcome in childhood malignant gliomas. 9000573 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Using immunohistochemical analysis, 4 of 10 confirmed malignant gliomas had over-expression of p53. 8847560 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Our data indicate that p53 gene mutation predisposes to decreased cell killing via chemotherapy in malignant gliomas. 8682593 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE We have studied alterations of the p53 gene in 27 patients with malignant gliomas. 8019958 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. 8504413 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression. 1501894 1992
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 Biomarker disease BEFREE Association of Notch-1, osteopontin and stem-like cells in ENU-glioma malignant process. 30140373 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 Biomarker disease BEFREE The literature review suggests that OPN may play important roles in the development and progression of selected cancers of children and young adults, including acute lymphoblastic leukemia, malignant gliomas, AT/RT and Langerhans cell histiocytosis. 28326824 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 AlteredExpression disease BEFREE Our findings show re-activation of the embryonic-type transcriptional regulation of SPP1 in malignant gliomas and point to the importance of SPP1-CD44 interactions in self-renewal and pluripotency glioma initiating cells. 28030801 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 AlteredExpression disease BEFREE Osteopontin and splice variant expression level in human malignant glioma: radiobiologic effects and prognosis after radiotherapy. 23891093 2013
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 AlteredExpression disease BEFREE Five potential markers (CD44 antigen (CD44), growth arrest and DNA-damage-inducible, alpha (GADD45A), fibronectin 1 (FN1), CD63 antigen (CD63) and secreted phosphoprotein 1 (SPP1)) showed expression patterns that correlated significantly with malignant glioma. 20150644 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 Biomarker disease RGD Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 Biomarker disease CTD_human Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633 2006
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.560 Biomarker disease BEFREE Elucidation of regulatory mechanisms for OPN induction in glioma cells should facilitate rational design of novel therapeutics for human malignant gliomas. 9615723 1998
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 Biomarker disease CTD_human Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. 30619488 2018
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 Biomarker disease MGD
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. 30738431 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE • APT signals were significantly higher in IDH-wild type compared to IDH-mutant high-grade glioma. 31175415 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation disease BEFREE In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma. 30972500 2019
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
0.400 Biomarker disease BEFREE As such, MGMT is gaining increasing traction in diagnosis, prognostication, and therapeutic decision-making for these highly malignant gliomas. 30444735 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE PET with <sup>18</sup>F-GE-180 and <sup>18</sup>F-FET provides differing imaging information in HGG dependent on the IDH-mutational status, with diverging spatial overlap and vast exceedance of contrast-enhancement in MRI. 30244386 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE We retrospectively analyzed 47 patients who underwent an advanced-MR study with DTI followed by surgical intervention with a subsequent histologic diagnosis of High-Grade Glioma (HGG) and immunohistochemical evaluation of IDH1 (Isocitrate DeHydrogenase) mutation status. 31153561 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE In contrast, mutations of phosphatase and tensin homolog (PTEN) and tumor protein 53 (TP53) appeared to be higher in HGG tumors in CC patients than in their AA counterparts. 29599344 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE Most IDH-wildtype tumors showing histopathological and radiological features of low-grade diffuse astrocytoma exhibit molecular and clinical features of high-grade glioma and may represent an early stage of primary glioblastoma. 29444314 2018