Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. 28401302 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising in adults, have a substantially lower incidence of genomic alterations of PTEN. 20607350 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules. 16773187 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts. 17310280 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. 17328268 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Furthermore, this signaling pathway was altered by either PTEN mutations or PIK3CA amplification in 10 of 12 (83%) malignant glioma cell lines analyzed. 17235514 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE Importantly, not only rapamycin-sensitive malignant glioma cells with PTEN mutations but also rapamycin-resistant malignant glioma cells with wild-type PTEN were sensitized to rapamycin by mTOR siRNA. 17001313 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma. 15679305 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE We sequenced kinase domains in the EGFR and human EGFR type 2 (Her2/neu) genes and analyzed the expression of EGFR, EGFR deletion mutant variant III (EGFRvIII), and the tumor-suppressor protein PTEN in recurrent malignant gliomas from patients who had received EGFR kinase inhibitors. 16282176 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE Our studies suggest that adenovirus-mediated combined TIMP-2 and PTEN gene therapy is possibly useful for anti-invasion therapy of malignant glioma. 15363547 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression disease BEFREE Inactivation of the tumor suppressor gene PTEN and overexpression of VEGF are two of the most common events observed in high-grade malignant gliomas. 12509854 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease CTD_human A novel germline mutation of PTEN associated with brain tumours of multiple lineages. 12085208 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis. 11678426 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker disease BEFREE PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. 10435616 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation disease BEFREE PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. 9484844 1998