Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. 30738431 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Dysfunction of the p53 pathways is common in malignant gliomas. 29435080 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation. 29756546 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE In contrast, mutations of phosphatase and tensin homolog (PTEN) and tumor protein 53 (TP53) appeared to be higher in HGG tumors in CC patients than in their AA counterparts. 29599344 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Previous studies have demonstrated that p53 dysfunction contributes to the development and severity of malignant glioma. 29731836 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. 26470725 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Furthermore, the p53 tumor suppressor, which has emerged as a key regulator of mitochondrial respiration at the expense of glycolysis, is genetically inactivated in a large proportion of HGG cases. 25583481 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_mouse PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_human We identified recurrent somatic mutations in ACVR1 exclusively in DIPGs (32%), in addition to previously reported frequent somatic mutations in histone H3 genes, TP53 and ATRX, in both DIPGs and NBS-HGGs. 24705251 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE For children with TP53 mutant malignant gliomas, one year overall survival was 63 ± 12 and 23 ± 10 % for ALT positive and negative tumors, respectively (p = 0.03), while for children with TP53 mutant choroid plexus carcinomas, 5 years overall survival was 67 ± 19 and 27 ± 13 % for ALT positive and negative tumors, respectively (p = 0.07). 25315281 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Our aim was to investigate the relationship between mutant p53 and the prognosis of malignant glioma treated with temozolomide, and the regulation of mutant TP53 induced drug resistance, by molecular experimentation and a clinical trial. 24248532 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE TP53 mutations were present only in malignant gliomas, including three pGBMs and one case designated as PA with anaplastic features (with consultation opinion of pGBM). 24057326 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE TP53 mutation decreases the chemosensitivity of malignant gliomas to temozolomide. 23224642 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Of 158 tumors with sufficient tissue, 110 (70 %) showed nuclear cMYC immunopositivity--most frequent (95 %, χ(2) p = 0.0248) and intense (mean 1.33, ANOVA p = 0.0179) in anaplastic astrocytomas versus glioblastomas (63 %) or low grade gliomas (74 %). cMYC expression associated with younger age as well as p53 immunopositivity (OR = 3.6, p = 0.0332) and mutant IDH1 (R132H) (OR = 7.4, p = 0.06) among malignant gliomas in our cohort. 23934175 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Trans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53. 22528789 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Our results identified oncogenic mutations in TP53 (40%), PI3KCA (15%), and ATM/MPL (5%) while none were identified in a large number of other genes commonly mutated in malignant gliomas. 22190243 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Genomic instability and p53 alterations in patients with malignant glioma. 22664273 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE This study provided the first evidence showing that TIP-1 modulates p53 protein stability and is involved in the radioresistance of malignant gliomas, suggesting that antagonizing TIP-1 might be one novel approach to sensitize malignant gliomas to radiotherapy. 23028987 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_human A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. 21946351 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. 21397859 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Hypoxia inhibited p53 activation and subsequent astroglial differentiation of HGG precursors. 18832593 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks. 18089819 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Wilms tumor 1 expression in malignant gliomas and correlation of +KTS isoforms with p53 status. 17886559 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_human In vitro drug response and molecular markers associated with drug resistance in malignant gliomas. 16899598 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE These results indicate that PUMA, which is regulated under a tumor-specific expression system such as the hTERT promoter, may be better than p53 as a therapeutic tool for malignant gliomas. 15960600 2005