Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE 17β-estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner. 25592968 2015
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE MALAT1 knockdown suppressed OS cell growth and metastasis, induced OS cell apoptosis and delayed tumor growth in an OS xenograft model. 28560950 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE MALAT1 promoted osteosarcoma progression by modulating stem cell-like properties. 30481748 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE Additionally, MALAT1 expression was correlated with tumor size, clinical stage and distant metastasis in patients with OS. 30365098 2019
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Additionally, EZH2 is highly expressed and associated with the 3' end region of lncRNA MALAT1 in osteosarcoma, and this association finally suppressed the expression of E-cadherin. 28388584 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE Besides these, CDK9 was predicted as a downstream gene of miR-206, and we observed that MALAT1 can regulate osteosarcoma progress by modulating CDK9 expression via sponging miR-206. 30076726 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Furthermore, the gain and loss function assay showed that miR-205 was suppressed by MALAT1 in osteosarcoma and this interaction between miR-205 and MALAT1 has reciprocal effects. 29290978 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE Here, we showed that MALAT1 and HMGB1 were significantly increased in human OS cell lines and knockdown of MALAT1 reduced HMGB1 expression. 28346809 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Knockdown of MALAT1 inhibited the proliferation and invasion of human osteosarcoma cell and suppressed its metastasis in vitro and vivo. 25431257 2015
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Meanwhile, we demonstrated that a depression of MALAT1 suppressed proliferation and promoted apoptosis in OS cell line HOS and 143B. 30094957 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT‑1) has been reported to upregulated and epigenetically regulate the metastasis in osteosarcoma; however, the regulatory mechanisms of MALAT‑1 expression remain unclear. 28098894 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE miR-425-5p decreases LncRNA MALAT1 and TUG1 expressions and suppresses tumorigenesis in osteosarcoma via Wnt/β-catenin signaling pathway. 30986552 2019
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Moreover, MALAT1 may be an independent predictive factor for OS in patients living with osteosarcoma. 31734255 2019
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Our results demonstrated the clinical prognostic significance and roles of MALAT1 in osteosarcoma, and suggested that MALAT1 may be considered as a prognostic biomarker and therapeutic target for osteosarcoma. 27649655 2016
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Overall, our research showed promising potential for new treatment strategies based on epigenetic regulation targeting MALAT1, which will not only coordinate with the patient's immune system, but also eliminate OS in conjunction with chemotherapy. 29290771 2018
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a lncRNA, has been discovered to be closely related to OS progression and hypoxia responses which are associated with angiogenesis. 29209144 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE RESULTS We found that MALAT1 was frequently upregulated in osteosarcoma samples and cell lines and a high level of MALAT1 predicted poor overall survival in osteosarcoma patients. 30793707 2019
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 AlteredExpression disease BEFREE Suppression of FOXO1, identified as a regulatory transcriptional factor of MALAT1, was shown to be able to slow down both proliferation and metastases in OS cells, suggesting that targeting FOXO1 can be useful in the therapy of patients with OS. 28160461 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE The functional experiments show that a decreased MALAT1 could remarkably inhibit osteosarcoma cell metastasis and proliferation but induce cell cycle arrest, indicating that MALAT1 functioned as an oncogene in osteosarcoma. 28938647 2017
Entrez Id: 378938
Gene Symbol: MALAT1
MALAT1
0.100 Biomarker disease BEFREE Thus, MALAT1 may promote OS cell growth through inhibition of MIR376A, leading to increased expression of TGFA. 27458156 2016