Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE The results demonstrated that MALAT1 and CCND1 mRNA expression levels were upregulated and miR‑34a was downregulated in OS tissues and cells. 30365098 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE In summary, the findings in our study highlight that cyclin A2 repression by miRNAs of the miR-16 and miR-34 families is lost in aggressive OS. 30679313 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Aberrant expression of the transcription factor, runt-related transcription factor 2 (RUNX2), is a key pathological feature in osteosarcoma and associated with loss of p53 and miR-34 expression. 30637720 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE These results indicated that NEAT1 participated in the development of osteosarcoma as a ceRNA to competitively bind to miR-34a-5p and thus mediate HOXA13 expression. 31044561 2019
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis. 30519318 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Further exploration on the downstream network of miR-34a identified that blocking plasminogen activator inhibitor-1 (PAI-1) expression could restrain OS dedifferentiation into cancer stem-like cells by downregulating SRY-related-HMG box (Sox) 2. 29991717 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma. 30596759 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE lncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting miR-34a-5p in Osteosarcoma Cells. 28810936 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE The oncogene role of SNHG7 in vivo was also confirmed and found that knockdown of SNHG7 delayed the tumor growth with increased miR-34a level and Ki-67 level in OS tissues. 29989838 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE This study suggested that miR-34a-5p, DLL1 and the ATF2/ATF3/ATF4 signaling pathway-associated genes are the potential diagnostic and/or therapeutic targets for an effective chemotherapy of OS. 28281638 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Correction: MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene. 28948006 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE The potential combinational effect of miR-34a with celecoxib in osteosarcoma. 28650862 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Treatment of U2OS cells with cisplatin induced cell apoptosis by upregulation of c-Myc -dependent Bim expression; Osteosarcoma U2OS cells transfected with miR-34a mimics (miR-34a/U2OS) induced cell apoptosis and inhibited cell survival, and increased the sensitivity of U2OS cells to cisplatin. 29060932 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE The data of the present study indicated that the inhibitory role of miR‑34a on tumor growth and metastasis of osteosarcoma may function by reducing the maintenance of osteosphere self‑renewal capacity, elimination of tumorigenic ability and invasion of osteosarcoma in vitro. 28260055 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Our findings find out an important function of miR-34a as a novel tumor-suppressor in osteosarcoma pathogenesis through inhibition of DUSP1. 29312491 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE And the expression of C-IAP2 and Bcl-2 protein was drastically inhibited, and the activities of caspase-3 and caspase-9 were significantly increased after transfecting miR-34a onto osteosarcoma MG-63 cells. 28635396 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Independent actions of the model drugs DNA-intercalating doxorubicin, RNA-interfering miR-34a and protein-inhibiting sorafenib on DNA replication, RNA translation and protein kinase signaling in highly metastatic, human osteosarcoma 143B cells were demonstrated by the increase of γH2A.X foci formation, reduction of c-MET expression and inhibition of Erk1/2 phosphorylation, respectively, and optimal effects were found for triple-drug combination. 28415566 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Validating the coordinating role of miR-34a in microtubule destabilization, when miR-34a was combined with either microtubule inhibitors or chemotherapy, STMN1 phosphorylation was suppressed and there was greater cytotoxicity in osteosarcoma cells. 28275089 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE The angiotensin II type 1 receptor (AGTR1) gene, is one of the targets of miR-34a-5p in OS and thus negatively correlates with OS chemoresistance by systematic investigations of a multi-drug sensitive (G-292) and resistant (SJSA-1) OS cell lines. 28073349 2017
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Specifically, in this study, using systematic observations of multi-drug sensitive (G-292 and MG63.2) and resistant (SJSA-1 and MNNG/HOS) osteosarcoma (OS) cell lines, we showed that miR-34a-5p promotes the multi-drug resistance of OS through the receptor tyrosine kinase CD117, a direct target of miR-34a-5p. 27056900 2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE Inhibition of OS cell growth and invasion were associated with release of high levels of mature miR-34a from pre-miR-34a prodrug and consequently reduction of protein levels of many miR-34a target genes including SIRT1, BCL2, c-MET, and CDK6. 27216562 2016
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 AlteredExpression disease BEFREE The MREs of miR-34 and miR-122 ensured that the luciferase gene was expressed selectively in osteosarcoma cells. 25335093 2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE Several microRNAs including the miR-34 family have been implicated in osteosarcoma tumorigenesis via effects on the Notch signaling pathway. 26659003 2015
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 Biomarker disease BEFREE The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signalling pathway. 24957404 2014
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.100 GeneticVariation disease BEFREE A G>A variation in the pre‑miR‑34a coding region was found to be associated with higher OS morbidity. 25242229 2014