Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that SC repressed cell viability and migration and induced apoptosis in vitro, while combined SC and erlotinib treatment enhanced osteosarcoma growth suppression by preventing feedback activation of STAT3. 31422383 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE This study investigated whether miR-29 regulates the STAT3 expression and affects the proliferation and apoptosis of osteosarcoma cells. 31539114 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE miR-340-5p gene expression in OS tissues and U2OS cells was significantly lower than that in paracancerous tissues and hFOB1.19 cells. miR-340-5p directly interacted with the 3'-untranslated region (3'-UTR) of STAT3 gene and negatively regulated its expression. 30779064 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Role of the HDAC6/STAT3 pathway in regulating PD-L1 expression in osteosarcoma cell lines. 30430228 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE These results collectively reveal that STAT3 regulates the transcription of STK35 in osteosarcoma. 29414823 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE <b>Conclusion:</b> These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway. 31371981 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Finally, blockade of STAT3 by WP1066 (a STAT3 inhibitor) further enhanced the effect of irisin on the EMT and Snail expression in osteosarcoma cells. 29048621 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that SOX18, IL-6 and p-STAT3 were elevated in osteosarcoma compared with bone cyst tissues. 29184419 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Stat3 upregulates leucine-rich repeat-containing g protein-coupled receptor 4 expression in osteosarcoma cells. 24455684 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE We found that CA concentration-dependently inhibited the activation of the STAT3/Snail pathway in osteosarcoma cells. 30582213 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 AlteredExpression disease BEFREE Furthermore, we showed that Stat3 activity was crucial for IL-17A/IL-17RA interaction to promote OS metastasis. 23192273 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE Importantly, TBL1XR1 enhanced the tumorigenicity of osteosarcoma cells via activating STAT3 signaling and TBL1XR1 expression correlated significantly with STAT3 phosphorylation in osteosarcoma. 30529193 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE In our previous work, we found that several canine and human osteosarcoma (OSA) cell lines, but not normal osteoblasts, exhibit constitutive phosphorylation of STAT3. 21443800 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE In addition, knockdown of LIF notably suppressed the proliferation and invasion of osteosarcoma via blocking the STAT3 signal pathway; in contrast, treatment with the recombinant LIF protein significantly promoted the growth and invasion of osteosarcoma through enhancing the phosphorylation of STAT3, which can be partially neutralized by the STAT3 inhibitor, HO-3867. 26271643 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 PosttranslationalModification disease BEFREE STAT3 phosphorylation has been demonstrated in a subset of human osteosarcoma (OSA) tissues and cell lines. 19284568 2009
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Additionally, signal transducer and activator of transcription 3 (STAT3) activation was suppressed by RA in human osteosarcoma, and this suppression was restored by GSH, SP600125, and JNK-shRNA. 30907478 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE AK093407 is highly expressed in osteosarcoma cells and tissues, and promotes cell proliferation and viability and inhibits apoptosis of osteosarcoma cell line U-2OS via STAT3 activation. 28469961 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE 4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells. 28386742 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Collectively, the results of this study demonstrated that BD exerts a strong inhibitory effect on tumor growth and stem cell like traits of osteosarcoma which may be partially due to STAT3 inhibition, suggesting that BD maybe a promising therapeutic candidate against osteosarcoma. 31631559 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. 28861175 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The miR-125b-MAPK-STAT3 axis may be one of the mechanisms of OS oncogenesis and a potential target for the treatment of OS. 30277613 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In this study, we investigated the antitumor effect of napabucasin (NP) (BBI608), an inhibitor of STAT3 on osteosarcoma in vitro and in vivo and studied the underlying molecular mechanism. 30286779 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In summary, the present studies revealed that the loss of CtBP2 constrained distant metastasis through the JAK1/Stat3 pathway in OS, suggesting that targeting CtBP2 may be a practical anti-tumor approach to prevent OS tumor progression. 31214864 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS. 30936718 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Immunohistochemistry showed that the staining of STAT3 protein was mainly located in cytoplasm of osteosarcoma cells in osteosarcoma tissue samples. 20546860 2011