Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Additionally, signal transducer and activator of transcription 3 (STAT3) activation was suppressed by RA in human osteosarcoma, and this suppression was restored by GSH, SP600125, and JNK-shRNA. 30907478 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE AK093407 is highly expressed in osteosarcoma cells and tissues, and promotes cell proliferation and viability and inhibits apoptosis of osteosarcoma cell line U-2OS via STAT3 activation. 28469961 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE 4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells. 28386742 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Collectively, the results of this study demonstrated that BD exerts a strong inhibitory effect on tumor growth and stem cell like traits of osteosarcoma which may be partially due to STAT3 inhibition, suggesting that BD maybe a promising therapeutic candidate against osteosarcoma. 31631559 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. 28861175 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The miR-125b-MAPK-STAT3 axis may be one of the mechanisms of OS oncogenesis and a potential target for the treatment of OS. 30277613 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In this study, we investigated the antitumor effect of napabucasin (NP) (BBI608), an inhibitor of STAT3 on osteosarcoma in vitro and in vivo and studied the underlying molecular mechanism. 30286779 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In summary, the present studies revealed that the loss of CtBP2 constrained distant metastasis through the JAK1/Stat3 pathway in OS, suggesting that targeting CtBP2 may be a practical anti-tumor approach to prevent OS tumor progression. 31214864 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS. 30936718 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Immunohistochemistry showed that the staining of STAT3 protein was mainly located in cytoplasm of osteosarcoma cells in osteosarcoma tissue samples. 20546860 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In addition, we detected the expression of vascular endothelial growth factor (VEGF) and signal transducer and activator of transcription 3 (STAT3) in osteosarcoma cell treated with Eag1 small interfering RNAs (siRNAs). 26783521 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Thus, AMBN induced a tumor suppressive phenotype and chemosensitivity to doxorubicin via the AMBN-Src-Stat3 axis in osteosarcoma. 28054649 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Furthermore, siRNA-mediated STAT3 inhibition in osteosarcoma cells decreased cell proliferation and invasion and down-regulated MMP2/9 expression. 28423603 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Alternol, a natural compound, exerts an anti-tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways. 27624867 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Our findings provide information about the underlying mechanisms of miR-204/14-3-3ζ in OS cell proliferation through the STAT3 pathway, and suggest miR-204 and 14-3-3ζ as potential therapeutic targets in OS. 29441884 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. 28750090 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Therefore, the discovery of novel molecular compounds that can effectively block STAT3 activation, is essential for the treatment of OS and improving prognosis. 30659925 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The findings demonstrated that ginkgetin exerts growth inhibitory and apoptotic effects on osteosarcoma cells through the inhibition of STAT3 and activation of caspase-3/9. 26573608 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes in osteosarcoma. 28783167 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A. 30745853 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The inhibition of STAT3 in Saos-2 cells by siRNA or AG490 decreased cell proliferation, migration and invasion, down-regulated the mRNA expression of Cyclin D, Bcl-xL and Survivin and enhanced the apoptotic response. 22743617 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE To sum up, deactivation of VEGFR2/STAT3/BCL-2 signal pathway leads to Apatinib-induced growth inhibition of osteosarcoma. 28837148 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion. 31667786 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE MAX interactor 1, dimerization protein (MXI1), STAT3 and T-cell acute lymphocytic leukemia 1 (TAL1) were significant TFs enriched with target genes in OS samples. 29234590 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma. 31534119 2019