Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2662
Gene Symbol: GDF10
GDF10
0.010 Biomarker disease BEFREE Purification and partial identification of bone-inducing protein from a murine osteosarcoma. 1320380 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE If both RB1 and TP53 are involved in the initiation of osteosarcoma, the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different. 1336709 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Therefore, in this case neither RB1 nor TP53 seems to play an essential role in the initiation of osteosarcoma. 1423318 1992
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.100 Biomarker disease BEFREE Soluble chromium (VI) compounds either alone or in combination with 3-methylcholanthrene (MC) were used to transform non-tumorigenic osteoblast-like human osteosarcoma cells (HOS TE85). 1423871 1992
Entrez Id: 23291
Gene Symbol: FBXW11
FBXW11
0.100 Biomarker disease BEFREE Soluble chromium (VI) compounds either alone or in combination with 3-methylcholanthrene (MC) were used to transform non-tumorigenic osteoblast-like human osteosarcoma cells (HOS TE85). 1423871 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE We analyzed 14 native osteosarcoma tissue samples for alterations of the tumor suppressor genes RB1 and p53 on the DNA level, and as far as possible, the RNA level. 1524989 1992
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE This result suggests that, in addition to the RB (retinoblastoma) gene on 13q and the p53 gene on 17p, at least two more tumor suppressor genes located on 3q and 18q are frequently involved in the development of osteosarcoma. 1568211 1992
Entrez Id: 4633
Gene Symbol: MYL2
MYL2
0.010 AlteredExpression disease BEFREE In this report, we show that when human osteosarcoma derived clonal cells (TE 85 clone F-5) (HOS), which are immortalized and nontumorigenic, undergo transformation following infection by Kirsten murine sarcoma virus (K-HOS) or by a chemical carcinogen [N-methyl-N-nitro-N-nitrosoguanidine (MNNG-HOS)], the smooth muscle MLC-2 mRNA is repressed. 1599878 1992
Entrez Id: 10398
Gene Symbol: MYL9
MYL9
0.010 AlteredExpression disease BEFREE In this report, we show that when human osteosarcoma derived clonal cells (TE 85 clone F-5) (HOS), which are immortalized and nontumorigenic, undergo transformation following infection by Kirsten murine sarcoma virus (K-HOS) or by a chemical carcinogen [N-methyl-N-nitro-N-nitrosoguanidine (MNNG-HOS)], the smooth muscle MLC-2 mRNA is repressed. 1599878 1992
Entrez Id: 10627
Gene Symbol: MYL12A
MYL12A
0.010 AlteredExpression disease BEFREE In this report, we show that when human osteosarcoma derived clonal cells (TE 85 clone F-5) (HOS), which are immortalized and nontumorigenic, undergo transformation following infection by Kirsten murine sarcoma virus (K-HOS) or by a chemical carcinogen [N-methyl-N-nitro-N-nitrosoguanidine (MNNG-HOS)], the smooth muscle MLC-2 mRNA is repressed. 1599878 1992
Entrez Id: 103910
Gene Symbol: MYL12B
MYL12B
0.010 AlteredExpression disease BEFREE In this report, we show that when human osteosarcoma derived clonal cells (TE 85 clone F-5) (HOS), which are immortalized and nontumorigenic, undergo transformation following infection by Kirsten murine sarcoma virus (K-HOS) or by a chemical carcinogen [N-methyl-N-nitro-N-nitrosoguanidine (MNNG-HOS)], the smooth muscle MLC-2 mRNA is repressed. 1599878 1992
Entrez Id: 5741
Gene Symbol: PTH
PTH
0.100 Biomarker disease BEFREE From these data, we inferred that ALP activity in SaOS-2 cells can provide a useful index of the osteoblastic phenotype, and that ALP activity, collagen production, and PTH-linked adenylate cyclase were coordinately regulated in these osteoblast-like osteosarcoma cells (ie, selection of subpopulations for ALP activity coselected for collagen synthesis and PTH-linked synthesis of cAMP). 1651438 1991
Entrez Id: 5741
Gene Symbol: PTH
PTH
0.100 AlteredExpression disease BEFREE Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells. 1654784 1991
Entrez Id: 4953
Gene Symbol: ODC1
ODC1
0.020 AlteredExpression disease BEFREE Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells. 1654784 1991
Entrez Id: 613
Gene Symbol: BCR
BCR
0.010 Biomarker disease BEFREE Our results contribute further evidence that the 7.5 kb fragment harbors a Breakpoint Cluster Region (BCR) in osteosarcoma. 1698437 1990
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE Deletion and rearrangement of the p53 gene were also found in three out of five of the human osteosarcoma cell lines (MG-63, G-292, Saos-2). 1739619 1992
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.070 AlteredExpression disease BEFREE Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. 1846564 1991
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.070 AlteredExpression disease BEFREE We used human osteosarcoma cells (MG-63) and measured hVDR and GR mRNA levels after androgen, estrogen, glucocorticoid, progesterone, thyroid hormone, vitamin A and vitamin D treatments. 1846564 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 AlteredExpression disease BEFREE In contrast to osteosarcoma Saos-2 cells, expression of wild-type or mutant p53 protein in A673 cells had no effect on morphology or growth characteristics. 1923505 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE Recent developments of importance include an improved understanding of the importance of the p53 gene in the pathogenesis of osteosarcoma, the description of preclinical models, the development of improved imaging techniques for determining tumor extent and responsiveness to chemotherapy, and refinements in therapy. 1932229 1991
Entrez Id: 5154
Gene Symbol: PDGFA
PDGFA
0.010 Biomarker disease BEFREE The polymerase chain reaction (PCR) has been used to amplify sequences coding for the platelet-derived growth factor A chain (PDGFA) using mRNA populations derived from two transformed cell lines (a human osteosarcoma, U-2OS, and a human glioma, U-343) and from human umbilical vein cells. 2016070 1991
Entrez Id: 5925
Gene Symbol: RB1
RB1
0.100 GeneticVariation disease BEFREE Structural aberrations within the RB1 gene have been studied in fresh samples of eleven cases of osteosarcoma. 2036639 1991
Entrez Id: 6910
Gene Symbol: TBX5
TBX5
0.100 AlteredExpression disease BEFREE Thus, in addition to the recent discovery of estradiol receptors and estrogenic regulation of HOS TE85 cells, it is now evident that these osteoblast-like osteosarcoma cells also express high affinity androgen binding sites and can respond biologically to androgens. 2036957 1991
Entrez Id: 23291
Gene Symbol: FBXW11
FBXW11
0.100 AlteredExpression disease BEFREE Thus, in addition to the recent discovery of estradiol receptors and estrogenic regulation of HOS TE85 cells, it is now evident that these osteoblast-like osteosarcoma cells also express high affinity androgen binding sites and can respond biologically to androgens. 2036957 1991
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.030 AlteredExpression disease BEFREE High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. 2036957 1991