<b>Conclusion</b>: The results uncover a crucial role for ATF4 in blocking the progression and resistance response in RET/GRP78-positive human osteosarcoma.
<b>Conclusion:</b> These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.
<b>Conclusion:</b> These results demonstrated that the anti-OS effects of lycorine were at least partly due to the suppression of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2)/STAT3 pathway.
<b>Conclusions:</b> IRS4, as a new substrate of CHIP, is negatively regulated by CK1γ2 at the posttranslational level, and specific CK1γ2 agonists may be a potentially effective strategy for treating patients with osteosarcoma.
<b>Materials and methods:</b> The levels of 3,4-dihydroxyphenylacetic acid, norepinephrine, serotonin, and 5-hydroxyindoleacetic acid in cancer tissue and in adjacent and non-oncological bone tissue were analysed by high-performance liquid chromatography, and the gene expression of catecholamine receptors and of dopamine β-hydroxylase, monoaminoxidase, ki67, and Runx2 in the osteosarcoma tissue, tissue adjacent to the tumour, non-oncological bone, and human brain tissue was analysed by RT-PCR.
<b>Methods:</b> The expression of miR-495-3p in OS tissues and adjacent tissues from 30 patients was measured by reverse<i> </i>transcription-quantitative PCR (RT-qPCR).
<b>Objective:</b> To investigate the effects of miR-143-3p and MAPK7 on the proliferation, migration, and invasion of U2OS human osteosarcoma (OS) cells.
<b>Results:</b> FGF5 was significantly upregulated in OS tissues and cells, and closely associated with poor differentiation, larger tumor size, lymph node metastasis, and advanced TNM stage.
<i>In vitro</i> cytotoxicity of NKG2D-CAR<sup>+</sup> CD45RA<sup>-</sup> T cells against osteosarcoma was evaluated by performing conventional 4-hour europium-TDA release assays.
<i>In vitro</i> cytotoxicity of NKG2D-CAR<sup>+</sup> CD45RA<sup>-</sup> T cells against osteosarcoma was evaluated by performing conventional 4-hour europium-TDA release assays.